Dose conversion between animals and humans: a practical solution
By: Jacob, Shery
.
Contributor(s): Nair, Anroop B.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(3), Jul-Sep.Description: 600-607p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Selecting the most appropriate first-in-human and pharmacologically active dose for any
new drugs or biologicals is a crucial step before starting a clinical trial investigation in adult
healthy human subjects. Extrapolation of dose between various rodent and non-rodent
animal species is critical for biomedical researchers during initial drug development. The
objective of this review is to provide practical guidance on how allometric scaling based
on the body surface area normalization can be effectively utilized for dose conversion
between various animal species. The standard conversion factors are included to allow
dose translation between animals to humans and humans to animals expressed either in
mg/kg or mg/m2
. The estimation of a safe starting dose is important to ensure the safety
and tolerability of humans during phase-I clinical trials.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1359 |
Selecting the most appropriate first-in-human and pharmacologically active dose for any
new drugs or biologicals is a crucial step before starting a clinical trial investigation in adult
healthy human subjects. Extrapolation of dose between various rodent and non-rodent
animal species is critical for biomedical researchers during initial drug development. The
objective of this review is to provide practical guidance on how allometric scaling based
on the body surface area normalization can be effectively utilized for dose conversion
between various animal species. The standard conversion factors are included to allow
dose translation between animals to humans and humans to animals expressed either in
mg/kg or mg/m2
. The estimation of a safe starting dose is important to ensure the safety
and tolerability of humans during phase-I clinical trials.
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