Study on the effect of phaseolus vulgaris methanol extract on haloperidol and tacrine induced parkinsonism
By: Kaur, Balvinder
.
Contributor(s): Saxena, Jyoti.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(3), Jul-Sep.Description: 804-809p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: Parkinson’s disease is neurodegenerative disease with no cure till now, there
are treatments that can be explored to ease the symptoms of this disease, and using plant
extract we explore the possibility of neutralizing the adverse symptoms and providing
better quality of life to patients. Purpose: To demonstrate Anti-parkinson’s activity of
Phaseolus vulgaris methanol pod extract by using behavioural models in
Wister Albino
rats. Materials and Methods: Animals were given
Phaseolus vulgaris methanol extract
(PVME) prior Haloperidol and Tacrine induced Parkinsonism. Results:
Phaseolus vulgaris,
family (Leguminosae) is a plant, well known for its Traditional and Ayurvedic application
for the treatment of various diseases. In the present studies,
Phaseolus vulgaris pods
were used to evaluate its Antiparkinson’s activity in behavioral models in Albino rats.
The models used here were Haloperidol-induced catalepsy and Tacrine-induced vacuous
jaw movement.
Phaseolus vulgaris methanol extract (PVME) of 200 and 400 mg/kg were
given to rats prior to inducing Catalepsy. Haloperidol, an Antipsychotic drug that induces
motor symptoms like Parkinson’s disease, PVME administration for 5 days, and on last
day Haloperidol (1mg/kg i.p) was given and catalepsy was observed, it was seen that
PVME reduces catalepsy score in a dose-dependent manner. Behavioral parameters also
observed using Tacrine, which is an Anticholesterase drug induces chewing movements
and orofacial bursts. The results were noted for a duration of 1 hr and found that PVME
400 mg/kg dose significantly reduces the movements and bursts as compared to
200 mg/kg dose. The given results were found close to the standard group (levodopa +
carbidopa). Conclusion: The study conducted on
Phaseolus vulgaris plant pod extract
demonstrates the Neuroprotective activity of plant and its effectiveness to assess
the symptoms of Parkinson’s disease. Antiparkinson’s effect of PVME shown to treat
symptoms of motor dysfunction attributed to its tendency to reduce oxidative stress and
having phenolic content.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1391 |
Background: Parkinson’s disease is neurodegenerative disease with no cure till now, there
are treatments that can be explored to ease the symptoms of this disease, and using plant
extract we explore the possibility of neutralizing the adverse symptoms and providing
better quality of life to patients. Purpose: To demonstrate Anti-parkinson’s activity of
Phaseolus vulgaris methanol pod extract by using behavioural models in
Wister Albino
rats. Materials and Methods: Animals were given
Phaseolus vulgaris methanol extract
(PVME) prior Haloperidol and Tacrine induced Parkinsonism. Results:
Phaseolus vulgaris,
family (Leguminosae) is a plant, well known for its Traditional and Ayurvedic application
for the treatment of various diseases. In the present studies,
Phaseolus vulgaris pods
were used to evaluate its Antiparkinson’s activity in behavioral models in Albino rats.
The models used here were Haloperidol-induced catalepsy and Tacrine-induced vacuous
jaw movement.
Phaseolus vulgaris methanol extract (PVME) of 200 and 400 mg/kg were
given to rats prior to inducing Catalepsy. Haloperidol, an Antipsychotic drug that induces
motor symptoms like Parkinson’s disease, PVME administration for 5 days, and on last
day Haloperidol (1mg/kg i.p) was given and catalepsy was observed, it was seen that
PVME reduces catalepsy score in a dose-dependent manner. Behavioral parameters also
observed using Tacrine, which is an Anticholesterase drug induces chewing movements
and orofacial bursts. The results were noted for a duration of 1 hr and found that PVME
400 mg/kg dose significantly reduces the movements and bursts as compared to
200 mg/kg dose. The given results were found close to the standard group (levodopa +
carbidopa). Conclusion: The study conducted on
Phaseolus vulgaris plant pod extract
demonstrates the Neuroprotective activity of plant and its effectiveness to assess
the symptoms of Parkinson’s disease. Antiparkinson’s effect of PVME shown to treat
symptoms of motor dysfunction attributed to its tendency to reduce oxidative stress and
having phenolic content.
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