Perspectives of presynaptic autoreceptors and presynaptic heteroreceptors in the mechanism of neurotransmission
By: Gawade, Shivaji Prataprao
.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(2), Apr-June.Description: 329-346p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: The presynaptic autoreceptors and / or presynaptic heteroreceptors of the principal
neurotransmitters involved in the release mechanism of neurotransmission have
been identified employing various experimental models, based on receptor types /
receptor subtypes and it’s stimulatory or inhibitory functions. The pharmacological,
neurophysiological, neurobiochemical
in vivo or
in vitro insect, animal or human prototype
experimental models were selected from the exhaustive search of literature published in
standard journals using, Google search engine, to identify the presynaptic autoreceptors
or presynaptic heteroreceptors. The complexity of neuronal function in nervous system
is based on the expression of presynaptic autoreceptors controlling / regulating the
release and that of presynaptic heteroreceptors activated by the neurotransmitter /
modulator released from other axon terminal communicated inter/ intraneuronally. In
the present review, eight types of prominent presynaptic auto or heteroreceptors of
seven neurotransmitters of central and peripheral nervous system namely cholinergic
muscarinic, cholinergic nicotinic, adrenergic, serotonergic, dopaminergic, histaminergic,
glutaminergic and GABArgic and their subtypes were classified according to stimulatory
or inhibitory functions and explained on the basis of prototype experimental
in vitro /
in vivo tissue models.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1417 |
The presynaptic autoreceptors and / or presynaptic heteroreceptors of the principal
neurotransmitters involved in the release mechanism of neurotransmission have
been identified employing various experimental models, based on receptor types /
receptor subtypes and it’s stimulatory or inhibitory functions. The pharmacological,
neurophysiological, neurobiochemical
in vivo or
in vitro insect, animal or human prototype
experimental models were selected from the exhaustive search of literature published in
standard journals using, Google search engine, to identify the presynaptic autoreceptors
or presynaptic heteroreceptors. The complexity of neuronal function in nervous system
is based on the expression of presynaptic autoreceptors controlling / regulating the
release and that of presynaptic heteroreceptors activated by the neurotransmitter /
modulator released from other axon terminal communicated inter/ intraneuronally. In
the present review, eight types of prominent presynaptic auto or heteroreceptors of
seven neurotransmitters of central and peripheral nervous system namely cholinergic
muscarinic, cholinergic nicotinic, adrenergic, serotonergic, dopaminergic, histaminergic,
glutaminergic and GABArgic and their subtypes were classified according to stimulatory
or inhibitory functions and explained on the basis of prototype experimental
in vitro /
in vivo tissue models.
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