Investigation on In-vitro dissolution and tableting properties enhancement of etodolac using stearoyl polyoxyl-32-glycerides as novel solid melt carrier
By: Salunkhe, Pradnya
.
Contributor(s): Gurav, Prashant B.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(2), Apr-June.Description: 420-428p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Objectives: The objective of present study was to improve dissolution rate with tableting
properties of BCS class II drug Etodolac, by melt granulation and sublimation techniques.
Materials and Methods: The granules of etodolac were formulated using Gelucire 50/13.
The surface adsorbent Aerosil 200 was utilized. Both melt granulation and surface
adsorption method in conjunction with sublimating agent were used to formulate tablets
of Etodolac. Etodolac: Gelucire 50/13: Aerosil200 was used in different ratio for melt
granulation technique to improve dissolution and tableting properties. Results: Solubility
study of melt granules were carried out in different ratio. 1:2:1 ratio showed 25 fold
increases in solubility of Etodolac. This 1:2:1 (A4) ratio was selected to designate the
tablets along with super disintegrant and sublimating agents. Precompression and post-
compression parameters results were satisfactory for etodolac tablets. XRD and DSC
study showed that Etodolac crystallinity was completely disappeared in A4 melt granules.
In vitro drug release of formulation F4 and F8 containing crosscarmallose sodium and
menthol were found to be 94.64% and 98.14% drug release at the end of 24 and
20 min respectively. The dissolution statistics like MDT, %DE and DP10 for optimized
formulation F8 exhibited 8.90 min, 28.25% and 55.45% respectively. Conclusion: The
melt granulation technique is useful to improve dissolution of Etodolac ideally, along with
superior tableting properties.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1426 |
Objectives: The objective of present study was to improve dissolution rate with tableting
properties of BCS class II drug Etodolac, by melt granulation and sublimation techniques.
Materials and Methods: The granules of etodolac were formulated using Gelucire 50/13.
The surface adsorbent Aerosil 200 was utilized. Both melt granulation and surface
adsorption method in conjunction with sublimating agent were used to formulate tablets
of Etodolac. Etodolac: Gelucire 50/13: Aerosil200 was used in different ratio for melt
granulation technique to improve dissolution and tableting properties. Results: Solubility
study of melt granules were carried out in different ratio. 1:2:1 ratio showed 25 fold
increases in solubility of Etodolac. This 1:2:1 (A4) ratio was selected to designate the
tablets along with super disintegrant and sublimating agents. Precompression and post-
compression parameters results were satisfactory for etodolac tablets. XRD and DSC
study showed that Etodolac crystallinity was completely disappeared in A4 melt granules.
In vitro drug release of formulation F4 and F8 containing crosscarmallose sodium and
menthol were found to be 94.64% and 98.14% drug release at the end of 24 and
20 min respectively. The dissolution statistics like MDT, %DE and DP10 for optimized
formulation F8 exhibited 8.90 min, 28.25% and 55.45% respectively. Conclusion: The
melt granulation technique is useful to improve dissolution of Etodolac ideally, along with
superior tableting properties.
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