Synthesis, characterization and comparison of novel poly (sebacic anhydride) biopolymeric implants and microspheres for the controlled release of an anticancer drug
By: Kala, Shabari Girinath
.
Contributor(s): Chinni, Santhivardhan.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(2), Apr-June.Description: 429-437p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Aim: The purpose of this study was to investigate the comparative drug release kinetics
of implants and microspheres of an anticancer drug loaded onto a bio-degradable polymer.
Methods: Poly (sebacic anhydride) was synthesized using a melt-polycondensation
reaction, and its physicochemical properties were determined using gel permeation
chromatography, nuclear magnetic resonance, differential scanning calorimetry, and
Fourier transform infrared techniques. The polymer was used to encapsulate drugs via
the melt moulding technique for implants and the solvent evaporation technique for
microspheres. Results:
In-vitro degradation of implants showed a 95% degradation rate
in 6 days with the disappearance of the anhydride peak due to polymer hydrolysis.
The microspheres of size 63 ± 3 μm were found to be spherical and porous in optical
microscopy images
. In-vitro drug release from implants (85 ± 3.5%) and microspheres
(88 ± 4.5%) in pH 7.4 revealed similar sustained drug release following Higuchi kinetics.
Conclusion: There was no significant difference observed in drug release patterns from
implants and microspheres with the same quantity of polymer. Therefore, poly (sebacic
anhydride) could become a successful candidate for controlling the release of a drug over
a long period of time.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1427 |
Aim: The purpose of this study was to investigate the comparative drug release kinetics
of implants and microspheres of an anticancer drug loaded onto a bio-degradable polymer.
Methods: Poly (sebacic anhydride) was synthesized using a melt-polycondensation
reaction, and its physicochemical properties were determined using gel permeation
chromatography, nuclear magnetic resonance, differential scanning calorimetry, and
Fourier transform infrared techniques. The polymer was used to encapsulate drugs via
the melt moulding technique for implants and the solvent evaporation technique for
microspheres. Results:
In-vitro degradation of implants showed a 95% degradation rate
in 6 days with the disappearance of the anhydride peak due to polymer hydrolysis.
The microspheres of size 63 ± 3 μm were found to be spherical and porous in optical
microscopy images
. In-vitro drug release from implants (85 ± 3.5%) and microspheres
(88 ± 4.5%) in pH 7.4 revealed similar sustained drug release following Higuchi kinetics.
Conclusion: There was no significant difference observed in drug release patterns from
implants and microspheres with the same quantity of polymer. Therefore, poly (sebacic
anhydride) could become a successful candidate for controlling the release of a drug over
a long period of time.
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