Protective effect of the aqueous extract of cyamopsis tetragonoloba seed against the paracetamol-induced toxicity in female wistar albino rats
By: Simon, Jerine Peter
.
Contributor(s): Namachivayam, Arunraj.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(2), Apr-June.Description: 580-588p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: Paracetamol is also known as acetaminophen which is the most widely
and commonly used painkiller drug among the overall human population. On excess
usage and high dosage, paracetamol can cause liver injury, gastrointestinal damage
and kidney damage.
Cyamopsis tetragonoloba is the most commonly available
plant in India which has weight loss properties as well as used to treat cancer and
diabetes. Aim: This study is to estimate the potential effect of
C. tetragonoloba against
paracetamol-induced hepatotoxicity. Methodology: There were seven groups of rats
which were divided as follows:Group-1 as Normal control, Group-2 administrated
with paracetamol (900mg/kg b.w./day,
i.p.), Group-3 is induced with paracetamol
(900mg/kg b.w./day,
i.p.) and
C. tetragonoloba (500 mg/kg b.w./day,
p.o.), Group-4
is same as Group-3 however
C. tetragonoloba dosage differs as 1000 mg/kg b.w./
day,
p.o.,Group-5 is given with paracetamol (900 mg/kg b.w./day,
i.p.) and silymarin
(25 mg/kg b.w./day,
p.o.), Group-6and Group-7 is administrated with
C. tetragonoloba
(500 mg/kg b.w./day,
p.o.) and
C. tetragonoloba (1000 mg/kg b.w./day,
p.o.)
respectively. After 4 hrs of drug administration, the animals were sacrificed from which
blood and organs were collected for the toxicity study. The samples were used for the
analysis of liver and kidney enzyme markers, antioxidant assays and histopathological
changes. Conclusion: The study has proven that
C. tetragonoloba has a potential effect
on the toxicity-induced groups. On compared to the standard drugs,
C. tetragonoloba
has shown better results.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1451 |
Background: Paracetamol is also known as acetaminophen which is the most widely
and commonly used painkiller drug among the overall human population. On excess
usage and high dosage, paracetamol can cause liver injury, gastrointestinal damage
and kidney damage.
Cyamopsis tetragonoloba is the most commonly available
plant in India which has weight loss properties as well as used to treat cancer and
diabetes. Aim: This study is to estimate the potential effect of
C. tetragonoloba against
paracetamol-induced hepatotoxicity. Methodology: There were seven groups of rats
which were divided as follows:Group-1 as Normal control, Group-2 administrated
with paracetamol (900mg/kg b.w./day,
i.p.), Group-3 is induced with paracetamol
(900mg/kg b.w./day,
i.p.) and
C. tetragonoloba (500 mg/kg b.w./day,
p.o.), Group-4
is same as Group-3 however
C. tetragonoloba dosage differs as 1000 mg/kg b.w./
day,
p.o.,Group-5 is given with paracetamol (900 mg/kg b.w./day,
i.p.) and silymarin
(25 mg/kg b.w./day,
p.o.), Group-6and Group-7 is administrated with
C. tetragonoloba
(500 mg/kg b.w./day,
p.o.) and
C. tetragonoloba (1000 mg/kg b.w./day,
p.o.)
respectively. After 4 hrs of drug administration, the animals were sacrificed from which
blood and organs were collected for the toxicity study. The samples were used for the
analysis of liver and kidney enzyme markers, antioxidant assays and histopathological
changes. Conclusion: The study has proven that
C. tetragonoloba has a potential effect
on the toxicity-induced groups. On compared to the standard drugs,
C. tetragonoloba
has shown better results.
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