In vivo wound healing potential of raloxifene nanoemulsion gel for the management of postmenopausal cutaneous wounds
By: Singh, Tej Pratap
.
Contributor(s): Verma, Navneet.
Publisher: Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(2), Apr-Jun.Description: 589-599p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: Depletion in estrogen level(s) especially in postmenopausal women is
reported to have delayed wound healing effects; hence we have evaluated the wound
healing potential of raloxifene in rat model. Objectives: Investigating the wound healing
effects of raloxifene nanoemulsion for the management of postmenopausal cutaneous
wounds. Materials and Methods: The optimized nanoemulsion gel contains 0.072%
raloxifene hydrochloride. Female Wistar rats were used to investigate its wound healing
effects. After three months of ovariectomy, wound healing effect was observed in terms
of breaking strength, tensile strength, area of wound contraction, wound closure time,
hydroxyproline content and histopathological changes. Results: The nanoemulsion gel
exhibited better retention (34.31%) than its nanoemulsion. The raloxifene nanoemulsion
gel has no erythema and no eschar formation recorded, and it is safe for topical use.
In the incision wound model in ovariectomized rats, breaking (898±25g) and tensile
strengths (4.47±0.12 g/mm2
) in raloxifene treated groups were found to be higher than
the untreated control group. Additionally, in ovariectomized rats, wound contraction was
found to be 100% in the treated group s following 20 days of post-wounding, where
as in control group only 88% was contraction was observed. Also, more hydroxyproline
content in raloxifene treated ovariectomized rat was observed that recommend more
collagen content than the untreated ovariectomized rat but approximately similar effects
to untreated non-ovariectomized rats. Histopathological studies confirmed that the
raloxifene treated groups had more re-epithelialization, neo-vascularization, fibroblast
proliferation, and collagen deposition than the control group. Conclusion: These results
confirms that the raloxifene nanoemulsion gel has significant wound healing potential,
as observed in ovariectomized rats, which will be helpful in postmenopausal cutaneous
wound healing.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-1452 |
Background: Depletion in estrogen level(s) especially in postmenopausal women is
reported to have delayed wound healing effects; hence we have evaluated the wound
healing potential of raloxifene in rat model. Objectives: Investigating the wound healing
effects of raloxifene nanoemulsion for the management of postmenopausal cutaneous
wounds. Materials and Methods: The optimized nanoemulsion gel contains 0.072%
raloxifene hydrochloride. Female Wistar rats were used to investigate its wound healing
effects. After three months of ovariectomy, wound healing effect was observed in terms
of breaking strength, tensile strength, area of wound contraction, wound closure time,
hydroxyproline content and histopathological changes. Results: The nanoemulsion gel
exhibited better retention (34.31%) than its nanoemulsion. The raloxifene nanoemulsion
gel has no erythema and no eschar formation recorded, and it is safe for topical use.
In the incision wound model in ovariectomized rats, breaking (898±25g) and tensile
strengths (4.47±0.12 g/mm2
) in raloxifene treated groups were found to be higher than
the untreated control group. Additionally, in ovariectomized rats, wound contraction was
found to be 100% in the treated group s following 20 days of post-wounding, where
as in control group only 88% was contraction was observed. Also, more hydroxyproline
content in raloxifene treated ovariectomized rat was observed that recommend more
collagen content than the untreated ovariectomized rat but approximately similar effects
to untreated non-ovariectomized rats. Histopathological studies confirmed that the
raloxifene treated groups had more re-epithelialization, neo-vascularization, fibroblast
proliferation, and collagen deposition than the control group. Conclusion: These results
confirms that the raloxifene nanoemulsion gel has significant wound healing potential,
as observed in ovariectomized rats, which will be helpful in postmenopausal cutaneous
wound healing.
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