Cefuroxime induced drug eruptions: a systematic literature review
By: Aroza, R
.
Contributor(s): Elstin, Raj.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(2), Mar-Apr.Description: 240-246p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Skin reactions pose a great challenge to the treating physician in the differential diagnosis. Cefuroxime
with a good profile has the potential of being used as empirical therapy for a range of community acquired
infections. The purpose of the review was to identify and assess various cases of drug eruptions caused
by cefuroxime. The review was conducted in compliance with preferred reporting items for systematic
reviews and meta-analyses guidelines. A total of nine case reports were included for the current systematic
review in which the drug dose ranged from 500 mg/d to 1000 mg/d. The treatment duration varied from
1 d to 15 d across the studies. The indications for treatment were as per Food and Drug Administration
guidelines. The presentation of the skin reactions was found to be symmetric in nature either in the form
of erythematous rash alone or along with inflamed erosions and oozing. There was no fatal case reported.
In most of the cases, the reaction subsided on the withdrawal of the intervening drug. The use of multiple
doses of cefuroxime is prone to cause drug eruptions. Further research is necessary to understand the
occurrence of reaction to prevent misdiagnosis of such reactions. Patients on antibiotics should be subjected
to counseling on discharge regarding the occurrence of adverse drug reactions for better patient safety and
qualitative care.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-2165 |
Skin reactions pose a great challenge to the treating physician in the differential diagnosis. Cefuroxime
with a good profile has the potential of being used as empirical therapy for a range of community acquired
infections. The purpose of the review was to identify and assess various cases of drug eruptions caused
by cefuroxime. The review was conducted in compliance with preferred reporting items for systematic
reviews and meta-analyses guidelines. A total of nine case reports were included for the current systematic
review in which the drug dose ranged from 500 mg/d to 1000 mg/d. The treatment duration varied from
1 d to 15 d across the studies. The indications for treatment were as per Food and Drug Administration
guidelines. The presentation of the skin reactions was found to be symmetric in nature either in the form
of erythematous rash alone or along with inflamed erosions and oozing. There was no fatal case reported.
In most of the cases, the reaction subsided on the withdrawal of the intervening drug. The use of multiple
doses of cefuroxime is prone to cause drug eruptions. Further research is necessary to understand the
occurrence of reaction to prevent misdiagnosis of such reactions. Patients on antibiotics should be subjected
to counseling on discharge regarding the occurrence of adverse drug reactions for better patient safety and
qualitative care.
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