Ameliorative effects of raphanus sativus l., nyctanthes arbor-tristis l. and ficus palmata forssk. on calcium oxalate crystallization events of stone formation in vitro
By: Bawari, Sweta
.
Contributor(s): Tewari, Devesh.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(2), Mar-Apr.Description: 287-299p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Study demonstrates the antiurolithiatic potential of the three important plant species of the western
Himalayan region viz. Ficus palmata fruits, Raphanus sativus leaves and Nyctanthes arbor-tristis leaves in
vitro. Nucleation, growth and aggregation assays along with microscopic analysis of calcium oxalate crystals
was employed to investigate the antilithic effect of the hydroethanolic extracts of Ficus palmata fruits,
Raphanus sativus leaves and Nyctanthes arbor-tristis leaves on crystallization events of calcium oxalate
stone formation. Fourier-transform infrared spectroscopy and high performance liquid chromatography
analysis was employed for characterizing the phytoconstituents present in the extracts. All the three plant
extracts produced inhibition of nucleation, growth and aggregation, and reduction of number and size
of calcium oxalate crystals. A favorable morphological transformation of calcium oxalate crystals was
also witnessed in the presence of the hydroethanolic extracts of Raphanus sativus and Nyctanthes arbor-
tristis. Phytochemical investigation of the extracts revealed the presence of saponins, tannins, flavonoids
and polyphenolic compounds while Fourier transform-infrared spectroscopy and high performance
liquid chromatography analysis further substantiated the presence of polyphenolic compounds which are
known to be involved in producing the anticrystallization effect of the tested extracts. Study confirmed
that Ficus palmata fruits, Raphanus sativus leaves and Nyctanthes arbor-tristis leaves possess significant
anticrystallization activity against calcium oxalate crystals which may translate to brilliant antiurolithiatic
activity based on the effect of these extracts on various phases of urinary stone formation as witnessed in
the present study.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2170 |
Study demonstrates the antiurolithiatic potential of the three important plant species of the western
Himalayan region viz. Ficus palmata fruits, Raphanus sativus leaves and Nyctanthes arbor-tristis leaves in
vitro. Nucleation, growth and aggregation assays along with microscopic analysis of calcium oxalate crystals
was employed to investigate the antilithic effect of the hydroethanolic extracts of Ficus palmata fruits,
Raphanus sativus leaves and Nyctanthes arbor-tristis leaves on crystallization events of calcium oxalate
stone formation. Fourier-transform infrared spectroscopy and high performance liquid chromatography
analysis was employed for characterizing the phytoconstituents present in the extracts. All the three plant
extracts produced inhibition of nucleation, growth and aggregation, and reduction of number and size
of calcium oxalate crystals. A favorable morphological transformation of calcium oxalate crystals was
also witnessed in the presence of the hydroethanolic extracts of Raphanus sativus and Nyctanthes arbor-
tristis. Phytochemical investigation of the extracts revealed the presence of saponins, tannins, flavonoids
and polyphenolic compounds while Fourier transform-infrared spectroscopy and high performance
liquid chromatography analysis further substantiated the presence of polyphenolic compounds which are
known to be involved in producing the anticrystallization effect of the tested extracts. Study confirmed
that Ficus palmata fruits, Raphanus sativus leaves and Nyctanthes arbor-tristis leaves possess significant
anticrystallization activity against calcium oxalate crystals which may translate to brilliant antiurolithiatic
activity based on the effect of these extracts on various phases of urinary stone formation as witnessed in
the present study.
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