Effect and mechanism of beta asarone from acorus tatarinowii schott on neuron injury in rats with parkinson's disease
By: Liu, H
.
Contributor(s): Ren, Minqiong.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(2), Mar-Apr.Description: 400-406p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: To analyze the protective effect and mechanism of beta-asarone from Acorus tatarinowii on neuron
injury in rats with Parkinson's disease. Thirty five male Sprague Dawley rats were randomly selected
to establish the rat model of Parkinson's disease. The rats were divided into 5 groups as sham operation
group, model group, low dose beta-asarone group, medium dose beta-asarone group and high dose beta-
asarone group, with 7 rats in each group. Rats in the sham operation group and model group were injected
with the same amount of normal saline, while rats in the low dose group, middle dose group and high
dose group were injected with 10 mg/kg, 20 mg/kg and 40 mg/kg beta-asarone respectively. The behavior
and the expression of tyrosine hydroxylase, alpha-synuclein, superoxide dismutase, catalase, glutathione
peroxidase, interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, B-cell lymphoma 2-associated
X protein, B-cell lymphoma 2 and caspase-3 in brain tissue were detected level detection. Compared with
the sham operation group, the number of autonomic activities, roll down time, forelimb activity time, the
expression levels of alpha-synuclein, superoxide dismutase, catalase, glutathione peroxidase and B-cell
lymphoma 2 were significantly decreased and the expression levels of tyrosine hydroxylase, interleukin-1
beta, tumor necrosis factor-alpha, nitric oxide, interleukin-6, B-cell lymphoma 2-associated X protein
and caspase-3 were significantly increased in the model group (p<0.05) The expression levels of alpha-
synuclein, superoxide dismutase, catalase, glutathione peroxidase and B-cell lymphoma 2 were significantly
decreased, while the expression levels of tyrosine hydroxylase, interleukin-1 beta, tumor necrosis factor-
alpha, nitric oxide, interleukin-6, B-cell lymphoma 2-associated X protein and caspase-3 were significantly
increased (p<0.05). Low dose of beta-asarone may inhibit oxidative stress and inflammatory reaction,
inhibit cell apoptosis, inhibit the decrease of tyrosine hydroxylase expression and the overexpression of
alpha-synuclein, so as to play a certain neuroprotective role and reduce neuron damage.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2181 |
To analyze the protective effect and mechanism of beta-asarone from Acorus tatarinowii on neuron
injury in rats with Parkinson's disease. Thirty five male Sprague Dawley rats were randomly selected
to establish the rat model of Parkinson's disease. The rats were divided into 5 groups as sham operation
group, model group, low dose beta-asarone group, medium dose beta-asarone group and high dose beta-
asarone group, with 7 rats in each group. Rats in the sham operation group and model group were injected
with the same amount of normal saline, while rats in the low dose group, middle dose group and high
dose group were injected with 10 mg/kg, 20 mg/kg and 40 mg/kg beta-asarone respectively. The behavior
and the expression of tyrosine hydroxylase, alpha-synuclein, superoxide dismutase, catalase, glutathione
peroxidase, interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, B-cell lymphoma 2-associated
X protein, B-cell lymphoma 2 and caspase-3 in brain tissue were detected level detection. Compared with
the sham operation group, the number of autonomic activities, roll down time, forelimb activity time, the
expression levels of alpha-synuclein, superoxide dismutase, catalase, glutathione peroxidase and B-cell
lymphoma 2 were significantly decreased and the expression levels of tyrosine hydroxylase, interleukin-1
beta, tumor necrosis factor-alpha, nitric oxide, interleukin-6, B-cell lymphoma 2-associated X protein
and caspase-3 were significantly increased in the model group (p<0.05) The expression levels of alpha-
synuclein, superoxide dismutase, catalase, glutathione peroxidase and B-cell lymphoma 2 were significantly
decreased, while the expression levels of tyrosine hydroxylase, interleukin-1 beta, tumor necrosis factor-
alpha, nitric oxide, interleukin-6, B-cell lymphoma 2-associated X protein and caspase-3 were significantly
increased (p<0.05). Low dose of beta-asarone may inhibit oxidative stress and inflammatory reaction,
inhibit cell apoptosis, inhibit the decrease of tyrosine hydroxylase expression and the overexpression of
alpha-synuclein, so as to play a certain neuroprotective role and reduce neuron damage.
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