Network pharmacology based analysis of the mechanism of action of glutathione on heart failure
By: Song, Jing
.
Contributor(s): Lin, Weiqian.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(2), Mar-Apr.Description: 415-422p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian Journal of Pharmaceutical ScienceSummary: Glutathione is an important antioxidant that plays an important role in myocardial remodeling.
However, the exact mechanisms underlying the effects of glutathione on heart failure are elusive. This
study aimed to investigate the mechanisms of glutathione in heart failure treatment based on network
pharmacology technology. The gene expression profiles were downloaded from Gene Expression Omnibus
database (GSE133054). Differentially expressed genes were identified by Gene Ontology analysis and
Kyoto Encyclopedia of Genes and Genomes pathway analysis. A protein protein interaction network was
constructed to screen potential regulatory proteins. We identified 970 potential target genes of glutathione
and 2381 differentially expressed genes of heart failure, with 80 genes overlapping in both groups. Gene
Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the
important genes were mainly distributed in phosphatidylinositol 3 kinase-protein kinase B signaling
pathway, mitogen-activated protein kinase signaling pathway, lipid and atherosclerosis pathway. In
glutathione target genes-heart failure network analysis, 7 targets were identified, including tumor necrosis
factor, vascular endothelial growth factor A, fibronectin 1, serine proteinase inhibitor 1, insulin-like growth
factor binding protein 3, matrix metalloproteinase-1 and liquid oxygen, with serine proteinase inhibitor 1,
insulin-like growth factor binding protein 3, fibronectin 1 and liquid oxygen significantly over expressed
in heart failure. We utilized network pharmacology to systematically explore the mechanism of action of
glutathione on heart failure and identified genes and pathways as potential therapeutic targets for heart
failure.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-2183 |
Glutathione is an important antioxidant that plays an important role in myocardial remodeling.
However, the exact mechanisms underlying the effects of glutathione on heart failure are elusive. This
study aimed to investigate the mechanisms of glutathione in heart failure treatment based on network
pharmacology technology. The gene expression profiles were downloaded from Gene Expression Omnibus
database (GSE133054). Differentially expressed genes were identified by Gene Ontology analysis and
Kyoto Encyclopedia of Genes and Genomes pathway analysis. A protein protein interaction network was
constructed to screen potential regulatory proteins. We identified 970 potential target genes of glutathione
and 2381 differentially expressed genes of heart failure, with 80 genes overlapping in both groups. Gene
Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the
important genes were mainly distributed in phosphatidylinositol 3 kinase-protein kinase B signaling
pathway, mitogen-activated protein kinase signaling pathway, lipid and atherosclerosis pathway. In
glutathione target genes-heart failure network analysis, 7 targets were identified, including tumor necrosis
factor, vascular endothelial growth factor A, fibronectin 1, serine proteinase inhibitor 1, insulin-like growth
factor binding protein 3, matrix metalloproteinase-1 and liquid oxygen, with serine proteinase inhibitor 1,
insulin-like growth factor binding protein 3, fibronectin 1 and liquid oxygen significantly over expressed
in heart failure. We utilized network pharmacology to systematically explore the mechanism of action of
glutathione on heart failure and identified genes and pathways as potential therapeutic targets for heart
failure.
Click on an image to view it in the image viewer
There are no comments for this item.