Ameliorative effect of withania somnifera against imidacloprid induced alterations in oestrous cycle of female albino wistar rats
By: Soujanya, S
.
Contributor(s): Mekala, L.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(2), Mar-Apr.Description: 436-443p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The present experiment was aimed to assess imidacloprid induced alterations in oestrous cycle and
ameliorative effects of Withania somnifera in rats. 48 female albino Wistar rats were divided into four
groups of 12 animals each. Group 1 is control, group 2 is imidacloprid (30 mg/kg body weight/d), group 3 is
Withania somnifera (1 g/kg feed) and group 4 is imidacloprid+Withania somnifera (30 mg/kg body weight/
d+1 g/kg feed). The test chemical was administered daily by oral gavage for 30 d. Seven consecutive estrous
cycles were monitored in all the four groups by vaginal smear test. From each group, 6 rats were sacrificed
on 16 th d and remaining were sacrificed on 31st d. Blood samples were collected before sacrifice on 16th and
31st d of experiment for estimation of hormones in serum. A significant increase in length of oestrous cycle,
follicle stimulating hormone levels and decrease in oestrogen levels were noticed in group 2. It is concluded
that administration of Withania somnifera provided moderate protection against the imidacloprid induced
toxicity by regularization of oestrous cycle in rats due to its antioxidant and gonadotropic properties.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2185 |
The present experiment was aimed to assess imidacloprid induced alterations in oestrous cycle and
ameliorative effects of Withania somnifera in rats. 48 female albino Wistar rats were divided into four
groups of 12 animals each. Group 1 is control, group 2 is imidacloprid (30 mg/kg body weight/d), group 3 is
Withania somnifera (1 g/kg feed) and group 4 is imidacloprid+Withania somnifera (30 mg/kg body weight/
d+1 g/kg feed). The test chemical was administered daily by oral gavage for 30 d. Seven consecutive estrous
cycles were monitored in all the four groups by vaginal smear test. From each group, 6 rats were sacrificed
on 16 th d and remaining were sacrificed on 31st d. Blood samples were collected before sacrifice on 16th and
31st d of experiment for estimation of hormones in serum. A significant increase in length of oestrous cycle,
follicle stimulating hormone levels and decrease in oestrogen levels were noticed in group 2. It is concluded
that administration of Withania somnifera provided moderate protection against the imidacloprid induced
toxicity by regularization of oestrous cycle in rats due to its antioxidant and gonadotropic properties.
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