Comparative evaluation of triphala extract prepared using two methods
By: Giramkar, Shital Ashok
.
Contributor(s): Zanwar, A.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(2), Mar-Apr.Description: 513-518p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: In view of the wide usage of Triphala for large number of therapeutic indications, ethno medicinal practice
of extract preparation viz. extracting the three plants together (sample A) and mixing the extracts of
three plants prepared separately (sample B), were compared. Both the test samples were analyzed with
respect to their physicochemical, phytochemical and pharmacological profiles. In case of physicochemical
properties, ash values and moisture content of both samples were comparable. Sample A showed less acidic
nature and high water soluble extractive (96.15±1.7) value which was statistically significant (p<0.05).
Phytochemical estimation of gallic acid and ellagic acid by high-performance thin-layer chromatography
showed higher content in sample B (-97.7 ng/μg) and sample A (-49.2 ng/μg) respectively. Pharmacological
activity of both the samples was comparable for total phenol content, total antioxidant and free radical
scavenging activity. Although both samples inhibited the activities of acetylcholine esterase and lipase in
a concentration dependent manner; sample B showed better activity. Usually, multi-plant extracts were
proven more superior over single plant extracts. In our study extract prepared by mixing the extracts of
3 plants prepared separately showed better pharmacological activity profile than the extract prepared by
extracting the three plants togethers.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2212 |
In view of the wide usage of Triphala for large number of therapeutic indications, ethno medicinal practice
of extract preparation viz. extracting the three plants together (sample A) and mixing the extracts of
three plants prepared separately (sample B), were compared. Both the test samples were analyzed with
respect to their physicochemical, phytochemical and pharmacological profiles. In case of physicochemical
properties, ash values and moisture content of both samples were comparable. Sample A showed less acidic
nature and high water soluble extractive (96.15±1.7) value which was statistically significant (p<0.05).
Phytochemical estimation of gallic acid and ellagic acid by high-performance thin-layer chromatography
showed higher content in sample B (-97.7 ng/μg) and sample A (-49.2 ng/μg) respectively. Pharmacological
activity of both the samples was comparable for total phenol content, total antioxidant and free radical
scavenging activity. Although both samples inhibited the activities of acetylcholine esterase and lipase in
a concentration dependent manner; sample B showed better activity. Usually, multi-plant extracts were
proven more superior over single plant extracts. In our study extract prepared by mixing the extracts of
3 plants prepared separately showed better pharmacological activity profile than the extract prepared by
extracting the three plants togethers.
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