Antioxidant potential of pyrimidine derivatives against oxidative stress
By: Nair, Nisha
.
Contributor(s): Jaseela, Majeed.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(1), Jan-Feb.Description: 14-26p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The human body is under constant attack from oxidative stress which in turn induces the excessive
production of free radicals, particularly the reactive oxygen species in the body which causes damage
to cells, proteins and deoxyribonucleic acid. Free radicals are associated with progression of numerous
pathological disruptions in humans including cancer, inflammation, atherosclerosis, Alzheimer’s disease,
Parkinson’s disease and aging as well. Antioxidants are the so called “free radical scavengers” of the
body, with ability to reduce the risk of chronic diseases by diminishing oxidative damage. Pyrimidines are
heterocyclic molecule with ability to be utilized in therapeutics as antioxidant. Recently, novel approaches
have been made and significant progress has occurred in last few years to overcome damage caused by free
radical generation using pyrimidine derivatives. The current review focuses on synthesizable pyrimidine
derivatives that show promise towards future development as antioxidants with therapeutic purpose.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2214 |
The human body is under constant attack from oxidative stress which in turn induces the excessive
production of free radicals, particularly the reactive oxygen species in the body which causes damage
to cells, proteins and deoxyribonucleic acid. Free radicals are associated with progression of numerous
pathological disruptions in humans including cancer, inflammation, atherosclerosis, Alzheimer’s disease,
Parkinson’s disease and aging as well. Antioxidants are the so called “free radical scavengers” of the
body, with ability to reduce the risk of chronic diseases by diminishing oxidative damage. Pyrimidines are
heterocyclic molecule with ability to be utilized in therapeutics as antioxidant. Recently, novel approaches
have been made and significant progress has occurred in last few years to overcome damage caused by free
radical generation using pyrimidine derivatives. The current review focuses on synthesizable pyrimidine
derivatives that show promise towards future development as antioxidants with therapeutic purpose.
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