Microarray data analysis, structure prediction and development of b-cell lymphoma 2-associated athanogene 3 protein modulators
By: Devgun, M
.
Contributor(s): Lal,S.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(1), Jan-Feb.Description: 87-98p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: B-cell lymphoma 2-associated athanogene 3 protein is profoundly expressed in various cancer tissues, which
can lead to proliferation, migration and invasion of cancer. The raw data for microarray data analysis was
obtained from the dataset record GDS2918. The self-organizing map and k-means of the genesis led to the
identification of two clusters containing B-cell lymphoma 2-associated athanogene 3 gene among others;
cluster number 1 (consisting of 902 genes) from self-organizing map and cluster number 09 (consisting of
348 genes) from k-means. The post clustering tool, SimGene, of Easy M-A was exploited to establish 84
genes with similar expressions as that of B-cell lymphoma 2-associated athanogene 3. The neighbor-joining
method in molecular evolutionary genetics analysis version 5 clearly establishes the evolutionary similarity
in between B-cell lymphoma 2-associated athanogene 3 and Small glutamine rich tetratricopeptide repeat
containing beta. The EasyModeller was utilized for homology modeling of B-cell lymphoma 2-associated
athanogene 3 and Small glutamine rich tetratricopeptide repeat containing beta proteins. The protein data
bank files were subjected to Procheck in structural analysis and verification server, which evaluates by
Ramachandran plot. The selected models were further subjected to loop modeling and validation. Ligands
were identified by using DrugBank and were docked against B-cell lymphoma 2-associated athanogene
3 and Small glutamine rich tetratricopeptide repeat containing beta using AutoDock tool. This led to the
identification of two compounds, i.e., DB07503 and DB13715 with potential to modulate B-cell lymphoma
2-associated athanogene 3 and aid in the management of various cancers wherein B-cell lymphoma
2-associated athanogene 3 is profoundly overexpressed.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2223 |
B-cell lymphoma 2-associated athanogene 3 protein is profoundly expressed in various cancer tissues, which
can lead to proliferation, migration and invasion of cancer. The raw data for microarray data analysis was
obtained from the dataset record GDS2918. The self-organizing map and k-means of the genesis led to the
identification of two clusters containing B-cell lymphoma 2-associated athanogene 3 gene among others;
cluster number 1 (consisting of 902 genes) from self-organizing map and cluster number 09 (consisting of
348 genes) from k-means. The post clustering tool, SimGene, of Easy M-A was exploited to establish 84
genes with similar expressions as that of B-cell lymphoma 2-associated athanogene 3. The neighbor-joining
method in molecular evolutionary genetics analysis version 5 clearly establishes the evolutionary similarity
in between B-cell lymphoma 2-associated athanogene 3 and Small glutamine rich tetratricopeptide repeat
containing beta. The EasyModeller was utilized for homology modeling of B-cell lymphoma 2-associated
athanogene 3 and Small glutamine rich tetratricopeptide repeat containing beta proteins. The protein data
bank files were subjected to Procheck in structural analysis and verification server, which evaluates by
Ramachandran plot. The selected models were further subjected to loop modeling and validation. Ligands
were identified by using DrugBank and were docked against B-cell lymphoma 2-associated athanogene
3 and Small glutamine rich tetratricopeptide repeat containing beta using AutoDock tool. This led to the
identification of two compounds, i.e., DB07503 and DB13715 with potential to modulate B-cell lymphoma
2-associated athanogene 3 and aid in the management of various cancers wherein B-cell lymphoma
2-associated athanogene 3 is profoundly overexpressed.
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