Design and development of modified starch from indonesian cassava (manihot esculenta crantz) for enteric film coating polymer applications
By: Yusriadi, Y
.
Contributor(s): Sulastri, Evi.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(1), Jan-Feb.Description: 99-107p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The design and development of modified cassava starch from Indonesia for film enteric coating polymer
applications were conducted in this study. The cassava starch was physically modified by heating at 70°
to produce pregelatinized cassava starch, followed by chemically modified by esterification to produce
pregelatinized cassava starch phthalate. Pregelatinized cassava starch phthalate was formulated to
produce film coating polymer with variations of concentration. The results of film coating pregelatinized
cassava starch phthalate showed a lower solubility at pH 1.2 and higher at alkaline pH where the optimum
results are shown in formula 3 containing pregelatinized cassava starch phthalate with a concentration of
6 % and plasticizer 50 % of the total pregelatinized cassava starch phthalate. The solubility of formula
3 in acidic (pH 1.2) and alkaline medium (pH 7.2) were 11.42 %±2.06 % and 38.91 %±2.23 %, respectively.
The highest film polymer tensile strength and Young’s modulus was also shown in formula 3 with value of
1.14±0.379 MPa and 3.7×10-2 ±4.4×10-3 . These results suggest that pregelatinized cassava starch phthalate
has the potential to be utilized as a controlled release film coating polymer that has good mechanical
properties.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2224 |
The design and development of modified cassava starch from Indonesia for film enteric coating polymer
applications were conducted in this study. The cassava starch was physically modified by heating at 70°
to produce pregelatinized cassava starch, followed by chemically modified by esterification to produce
pregelatinized cassava starch phthalate. Pregelatinized cassava starch phthalate was formulated to
produce film coating polymer with variations of concentration. The results of film coating pregelatinized
cassava starch phthalate showed a lower solubility at pH 1.2 and higher at alkaline pH where the optimum
results are shown in formula 3 containing pregelatinized cassava starch phthalate with a concentration of
6 % and plasticizer 50 % of the total pregelatinized cassava starch phthalate. The solubility of formula
3 in acidic (pH 1.2) and alkaline medium (pH 7.2) were 11.42 %±2.06 % and 38.91 %±2.23 %, respectively.
The highest film polymer tensile strength and Young’s modulus was also shown in formula 3 with value of
1.14±0.379 MPa and 3.7×10-2 ±4.4×10-3 . These results suggest that pregelatinized cassava starch phthalate
has the potential to be utilized as a controlled release film coating polymer that has good mechanical
properties.
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