Development and validation of novel ultraviolet spectrophotometric method for estimation of antileishmanial drug buparvaquone
By: Shaikh, T. K
.
Contributor(s): Shelke, S. S.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(1), Jan-Feb.Description: 130-136p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: A novel, simple, accurate, precise, economical and reliable ultraviolet spectrophotometric method has been
developed for the estimation of buparvaquone in bulk and in pharmaceutical dosage form. The drug shows
maximum absorption at 251 nm by using acetonitrile as solvent. The method was validated as stated in
International Council for Harmonisation Q2 (R1) guidelines. It obeys Beer’s law in the concentration
range of 2-20 μg/ml with correlation coefficient of 0.998. The drug shows great accuracy close to 100 %.
The method was found to be robust and precise as the relative standard deviation are less than 2 %. Limit
of detection and limit of quantitation were found to be 0.60 μg/ml and 1.83 μg/ml respectively. From the
results of specificity, the drug was found to be more degraded under alkaline, oxidative and photolytic
conditions. The proposed method can be employed for the reliable quantification of buparvaquone in bulk
and routine analysis of pharmaceutical formulations.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2246 |
A novel, simple, accurate, precise, economical and reliable ultraviolet spectrophotometric method has been
developed for the estimation of buparvaquone in bulk and in pharmaceutical dosage form. The drug shows
maximum absorption at 251 nm by using acetonitrile as solvent. The method was validated as stated in
International Council for Harmonisation Q2 (R1) guidelines. It obeys Beer’s law in the concentration
range of 2-20 μg/ml with correlation coefficient of 0.998. The drug shows great accuracy close to 100 %.
The method was found to be robust and precise as the relative standard deviation are less than 2 %. Limit
of detection and limit of quantitation were found to be 0.60 μg/ml and 1.83 μg/ml respectively. From the
results of specificity, the drug was found to be more degraded under alkaline, oxidative and photolytic
conditions. The proposed method can be employed for the reliable quantification of buparvaquone in bulk
and routine analysis of pharmaceutical formulations.
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