Response surface method assisted fabrication and characterization of optimized aceclofenac loaded microspheres inculcated with multivariate polymers
By: Quazi, A
.
Contributor(s): Nazia Khanam.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(1), Jan-Feb.Description: 150-161p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The optimized microspheres were fabricated as a controlled release system for aceclofenac incorporating
polymeric cross-linking with sodium alginate as natural, hydrophilic polymer and Eudragit RS100
synthetic, hydrophobic polymer by ion-gelation technique. The method was optimized by Box Behnken
design incorporating concentration of pure drug, natural and synthetic polymer along with the obtained
responses that were mean particle size (Y1) and entrapment efficiency of drug (Y2). Microspheres were
characterized for percentage yield, micromeritic evaluation, particle size, entrapment efficiency of drug,
in vitro study, fourier transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic
resonance and high performance liquid chromatography quantification of optimized formulation. It was
observed that application of response surface method software for Box Behnken design yielded stable
and spherical microspheres with mean particle size 69.37 μm and entrapment efficiency of drug 79.86 %
for the most optimized formulation F5. We can conclude that bridging of aceclofenac with natural and
synthetic polymers yielded stable, cost effective microspheres bearing enhanced micromeritic properties
with controlled release effect.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2248 |
The optimized microspheres were fabricated as a controlled release system for aceclofenac incorporating
polymeric cross-linking with sodium alginate as natural, hydrophilic polymer and Eudragit RS100
synthetic, hydrophobic polymer by ion-gelation technique. The method was optimized by Box Behnken
design incorporating concentration of pure drug, natural and synthetic polymer along with the obtained
responses that were mean particle size (Y1) and entrapment efficiency of drug (Y2). Microspheres were
characterized for percentage yield, micromeritic evaluation, particle size, entrapment efficiency of drug,
in vitro study, fourier transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic
resonance and high performance liquid chromatography quantification of optimized formulation. It was
observed that application of response surface method software for Box Behnken design yielded stable
and spherical microspheres with mean particle size 69.37 μm and entrapment efficiency of drug 79.86 %
for the most optimized formulation F5. We can conclude that bridging of aceclofenac with natural and
synthetic polymers yielded stable, cost effective microspheres bearing enhanced micromeritic properties
with controlled release effect.
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