Quantitative phytochemical profile, antioxidant and lipase inhibitory potential of leaves of momordica charantia L. and psoralea corylifolia L
By: Karale, Pushpa
.
Contributor(s): Dhawale, S. C.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(1), Jan-Feb.Description: 189-196p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Medicinal plants have recently gained popularity and are now commonly used to treat a variety of
diseases. The aim of this research was to evaluate antioxidant and anti-lipase activities of two commonly.
used medicinal plants in vitro. The solvents like chloroform, acetone and 70 % ethanol were used to
extract the dried leaves of Momordica charantia and Psoralea corylifolia. Folin-Ciocateu’s reagent and the
aluminum chloride colorimetry process were used to determine the total phenolic and flavonoid contents,
respectively. Further the extracts were screened for in vitro antioxidant activity, analyzed by 2,2-diphenyl-
1-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power assay. Using
pancreatic lipase enzyme inhibition, the anti-lipase potential of extracts was studied and compared to that
of the reference drug orlistat. The phytochemical analysis revealed that the ethanol extract of Momordica
charantia had the highest total phenolic and total flavonoid content (89.96±0.29 mg gallic acid equivalents/g
of dry extract; 82.55±0.03 mg quercetin equivalents/g of dry extract, respectively) of all the plant extracts
examined. The ethanol extract of Momordica charantia exhibited substantial radical scavenging and ferric
reducing potential, with IC50 values of 96.85±0.04 μg/ml and 99.43±0.06 μg/ml, respectively. Anti-lipase
activity was found in all of the extracts. The ethanol extract of Momordica charantia, on the other hand,
demonstrated strong anti-lipase activity, with an IC50 value of 27.70±0.15 μg/ml (p< 0.01). The standard
drug orlistat (18.15±0.34 μg/ml) showed the greatest anti-lipase activity. Overall, Momordica charantia
leaf extracts exhibited greater antioxidant and anti-lipase activity than Psoralea corylifolia. Momordica
charantia and Psoralea corylifolia were found to be powerful antioxidants and pancreatic lipase inhibitors.
A daily supplement of these plants, according to our findings, can aid in the reduction of obesity.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2252 |
Medicinal plants have recently gained popularity and are now commonly used to treat a variety of
diseases. The aim of this research was to evaluate antioxidant and anti-lipase activities of two commonly.
used medicinal plants in vitro. The solvents like chloroform, acetone and 70 % ethanol were used to
extract the dried leaves of Momordica charantia and Psoralea corylifolia. Folin-Ciocateu’s reagent and the
aluminum chloride colorimetry process were used to determine the total phenolic and flavonoid contents,
respectively. Further the extracts were screened for in vitro antioxidant activity, analyzed by 2,2-diphenyl-
1-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power assay. Using
pancreatic lipase enzyme inhibition, the anti-lipase potential of extracts was studied and compared to that
of the reference drug orlistat. The phytochemical analysis revealed that the ethanol extract of Momordica
charantia had the highest total phenolic and total flavonoid content (89.96±0.29 mg gallic acid equivalents/g
of dry extract; 82.55±0.03 mg quercetin equivalents/g of dry extract, respectively) of all the plant extracts
examined. The ethanol extract of Momordica charantia exhibited substantial radical scavenging and ferric
reducing potential, with IC50 values of 96.85±0.04 μg/ml and 99.43±0.06 μg/ml, respectively. Anti-lipase
activity was found in all of the extracts. The ethanol extract of Momordica charantia, on the other hand,
demonstrated strong anti-lipase activity, with an IC50 value of 27.70±0.15 μg/ml (p< 0.01). The standard
drug orlistat (18.15±0.34 μg/ml) showed the greatest anti-lipase activity. Overall, Momordica charantia
leaf extracts exhibited greater antioxidant and anti-lipase activity than Psoralea corylifolia. Momordica
charantia and Psoralea corylifolia were found to be powerful antioxidants and pancreatic lipase inhibitors.
A daily supplement of these plants, according to our findings, can aid in the reduction of obesity.
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