Estimation of pramipexole dihydrochloride in tablet formulation by the developed reverse phase high performance liquid chromatography method and its validation
By: Venkatesh, P
.
Contributor(s): Gayatri S.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(1), Jan-Feb.Description: 227-230p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: A simple, rapid isocratic reverse phase high performance liquid chromatography method was developed and
validated for the determination of pramipexole dihydrochloride in tablet dosage form as per International
Council on Harmonisation guidelines. In this method the chromatographic separation was carried out
using C18 column with ultraviolet detector set at 264 nm. The eluent consisted of acetonitrile:phosphate
buffer (pH 4.0) (70:30 by volume) with a flow rate of 1 ml/min. The method showed linear response with
the retention time of 2.28 min. The main advantage of the developed method is its cost effectiveness and
shortened run time. Hence this method can be applied for routine analysis of pramipexole in pharmaceutical
dosage form.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-2258 |
A simple, rapid isocratic reverse phase high performance liquid chromatography method was developed and
validated for the determination of pramipexole dihydrochloride in tablet dosage form as per International
Council on Harmonisation guidelines. In this method the chromatographic separation was carried out
using C18 column with ultraviolet detector set at 264 nm. The eluent consisted of acetonitrile:phosphate
buffer (pH 4.0) (70:30 by volume) with a flow rate of 1 ml/min. The method showed linear response with
the retention time of 2.28 min. The main advantage of the developed method is its cost effectiveness and
shortened run time. Hence this method can be applied for routine analysis of pramipexole in pharmaceutical
dosage form.
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