Hepatoprotective effect of hydroalcoholic extract of Qurse Afsanteen, apolyherbal Unani formulation, inchemically induced hepatotoxicity in rat
By: Abdullah
.
Contributor(s): Abdul Wadud.
Publisher: Mandsaur BRNSS Publication Hub. 2022Edition: Vol.16(3), Jul-Sep.Description: 281-286p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of green pharmacySummary: Aim: The liver plays a key role in the biotransformation of many chemicals and drugs. Thereby, it is a target organ
for several toxicants. Qurse Afsanteen, an Unani formulation, is claimed to be effective as a hepatoprotective.
Materials and Methods: To evaluate the hepatoprotective effect of hydroalcoholic extract of Qurse Afsanteen
(HAEQA) against CCl4 and Rifampicin induced hepatotoxicity, 36 rats were divided into six groups, each having six
animals representing negative, positive, standard, and test Groups A, B, and C. CCl4 was used in the dose of 0.7 ml/
kg for 7 days whereas Rifampicin was given in the dose of 100 mg/kg for 15 days for inducing hepatotoxicity. In
test and standard groups, CCl4 and Rifampicin were administered after 30 min of receiving test and standard drug.
Treatment Groups A, B, and C received HAEQA in three doses, that is, 40.32 mg, 67.2 mg, and 120.96 mg/kg
to observe the dose-dependent effect. Silymarin (100mg/kg) was used as standard drug. Serum markers, namely,
SGOT, SGPT, ALP, bilirubin, and cholesterol were estimated as parameter. Histopathology of the liver was also
done. Result and Discussion: HAEQA showed significant hepatoprotection at therapeutic dose level (67.2 mg/
kg) against CCl4 and Rifampicin-induced hepatotoxicity which is evident by decreased enzyme markers in both
methods. Conclusion: The findings were suggestive of the test drug possessing hepatoprotective activity.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-2299 |
Aim: The liver plays a key role in the biotransformation of many chemicals and drugs. Thereby, it is a target organ
for several toxicants. Qurse Afsanteen, an Unani formulation, is claimed to be effective as a hepatoprotective.
Materials and Methods: To evaluate the hepatoprotective effect of hydroalcoholic extract of Qurse Afsanteen
(HAEQA) against CCl4 and Rifampicin induced hepatotoxicity, 36 rats were divided into six groups, each having six
animals representing negative, positive, standard, and test Groups A, B, and C. CCl4 was used in the dose of 0.7 ml/
kg for 7 days whereas Rifampicin was given in the dose of 100 mg/kg for 15 days for inducing hepatotoxicity. In
test and standard groups, CCl4 and Rifampicin were administered after 30 min of receiving test and standard drug.
Treatment Groups A, B, and C received HAEQA in three doses, that is, 40.32 mg, 67.2 mg, and 120.96 mg/kg
to observe the dose-dependent effect. Silymarin (100mg/kg) was used as standard drug. Serum markers, namely,
SGOT, SGPT, ALP, bilirubin, and cholesterol were estimated as parameter. Histopathology of the liver was also
done. Result and Discussion: HAEQA showed significant hepatoprotection at therapeutic dose level (67.2 mg/
kg) against CCl4 and Rifampicin-induced hepatotoxicity which is evident by decreased enzyme markers in both
methods. Conclusion: The findings were suggestive of the test drug possessing hepatoprotective activity.
Click on an image to view it in the image viewer
There are no comments for this item.