Human follicular fluid, clinical use of proteomics analysis in identification of infertility
By: Gairola, Nidhi
.
Contributor(s): Deorari, Mahamedha.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 917-923p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Introduction: In present situation infertility is one of the chief problem for reproductive
couples due to multiple factors including lifestyle. Infertility is thought to be caused by
both male and female factors in 27 percent of cases, with 15 percent of cases being
idiopathic. Assisted reproductive technologies are used by these couples to overcome
the problems related to infertility, but the success rate of ART is appreciated by WHO
if it reaches to 30%. About 70% non-successful ART is due to the fact that molecular
mechanism of human reproductive system is poorly understood. Materials and Methods:
A systematic review was carried out using which pubmed, sciencedirect, scifinder, and
google scholar databases. We followed standard criterion of inclusion and exclusion
recommended by Cochrane review system. Information collected from the selected
articles were compared and summarized in tables and Figures. Results: Proteomics is
a promising approach for identifying possible biomarkers for infertility treatment and
management. The use of OMICS technology to develop diagnostic and therapeutic
techniques to increase the efficacy of ART is critical. Tandem mass spectrometry (LC-
MS/MS) is used to identify peptides in proteins. Using advance proteomics tools such as
SELDI-TOF, MALDI-TOF stressing the importance of protein in pregnancy maintenance
and fertilization. Conclusion: We conclude from this study that using proteomics analysis
can help in identifying potential biomarkers which can be used in the field of diagnostic
and therapeutic of infertility. Further serious and extensive research is very much required
in this field of research.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2023-0087 |
Introduction: In present situation infertility is one of the chief problem for reproductive
couples due to multiple factors including lifestyle. Infertility is thought to be caused by
both male and female factors in 27 percent of cases, with 15 percent of cases being
idiopathic. Assisted reproductive technologies are used by these couples to overcome
the problems related to infertility, but the success rate of ART is appreciated by WHO
if it reaches to 30%. About 70% non-successful ART is due to the fact that molecular
mechanism of human reproductive system is poorly understood. Materials and Methods:
A systematic review was carried out using which pubmed, sciencedirect, scifinder, and
google scholar databases. We followed standard criterion of inclusion and exclusion
recommended by Cochrane review system. Information collected from the selected
articles were compared and summarized in tables and Figures. Results: Proteomics is
a promising approach for identifying possible biomarkers for infertility treatment and
management. The use of OMICS technology to develop diagnostic and therapeutic
techniques to increase the efficacy of ART is critical. Tandem mass spectrometry (LC-
MS/MS) is used to identify peptides in proteins. Using advance proteomics tools such as
SELDI-TOF, MALDI-TOF stressing the importance of protein in pregnancy maintenance
and fertilization. Conclusion: We conclude from this study that using proteomics analysis
can help in identifying potential biomarkers which can be used in the field of diagnostic
and therapeutic of infertility. Further serious and extensive research is very much required
in this field of research.
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