Design, optimization, in vitro and in vivo evaluation of flurbiprofen loaded solid lipid nanoparticles (SLNs) topical gel
By: Keerthana, K
.
Contributor(s): Sandeep, D. S.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 984-993p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: The aim of present study was to carry out the formulation design and
evaluation of Solid Lipid Nanoparticles (SLNs) loaded topical gel of Flurbiprofen. Materials
and Methods: Flurbiprofen solid lipid nanoparticles (SLNs) were formulated using Glyceryl
monostearate (GMS) as lipid matrix by solvent evaporation method followed by probe
sonication. A 32 full factorial design was utilized to optimize the SLNs. Drug: lipid ratio
and sonication time were chosen as independent variables. Particle size, entrapment
efficiency (%) and PDI were dependent variables. The optimized Flurbiprofen SLNs was
formulated as topical gel and screened for pH, spredability, drug content, viscosity, drug
release study, TEM analysis and
in vivo skin irritation studies. Results: The optimized
SLNs-gel had particle size of 369.8 nm, entrapment efficiency of 70.66% and PDI of
0.241. The zeta potential was found to be -33.4 mV resembling the better stability. Drug
release study showed sustained release pattern with maximum release of 96.78% up to
10 hr following Highuchi kinetics mechanism. TEM study revealed that formulation had
particle size in the nano scale range.
In vivo skin irritation study on wister rats proved that
formulation didn’t had any signs of irritation. Conclusion: Based on the obtained results,
the study concluded that SLNs based Flurbiprofen gel can be better and promising topical
drug delivery approach.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-0094 |
Background: The aim of present study was to carry out the formulation design and
evaluation of Solid Lipid Nanoparticles (SLNs) loaded topical gel of Flurbiprofen. Materials
and Methods: Flurbiprofen solid lipid nanoparticles (SLNs) were formulated using Glyceryl
monostearate (GMS) as lipid matrix by solvent evaporation method followed by probe
sonication. A 32 full factorial design was utilized to optimize the SLNs. Drug: lipid ratio
and sonication time were chosen as independent variables. Particle size, entrapment
efficiency (%) and PDI were dependent variables. The optimized Flurbiprofen SLNs was
formulated as topical gel and screened for pH, spredability, drug content, viscosity, drug
release study, TEM analysis and
in vivo skin irritation studies. Results: The optimized
SLNs-gel had particle size of 369.8 nm, entrapment efficiency of 70.66% and PDI of
0.241. The zeta potential was found to be -33.4 mV resembling the better stability. Drug
release study showed sustained release pattern with maximum release of 96.78% up to
10 hr following Highuchi kinetics mechanism. TEM study revealed that formulation had
particle size in the nano scale range.
In vivo skin irritation study on wister rats proved that
formulation didn’t had any signs of irritation. Conclusion: Based on the obtained results,
the study concluded that SLNs based Flurbiprofen gel can be better and promising topical
drug delivery approach.
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