Dual-pulse release system of atenolol: preparation and in-vitro characterization
By: Kunjekar, Sonam Sanjayrao
.
Contributor(s): Singhavi, Dilesh Jagdish.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 1025-1030p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Aim: Hypertension exhibits a circadian rhythm and drugs need to be released at the time
when the blood pressure is elevated most. This elevation is pronounced at 7 pm and at 4
am. Atenolol is an anti-hypertensive drug with an absorption window mainly in the upper
section of the gastrointestinal tract. The present investigation was aimed at designing
floating pulsatile capsules for dual release of atenolol in the stomach for effective
management of hypertension. Materials and Methods: The floating pulsatile capsules
designed had different components: a formaldehyde-treated capsule body; an untreated
cap; a polymer plug layer, containing a polymer; two atenolol-containing immediate-
release tablets and a swellable polymer layer. The polymer plug layer was made of
hydroxypropyl methylcellulose (K4M or E50) and xanthan gum alone or in combination.
The capsules were characterized for weight variation, percent drug content,
in-vitro
release behaviour and floating property. Results: The outcomes of the
in-vitro studies
showed that lag duration between the two pulses of drug release from the formulations
can be adjusted by manipulating the composition of the plug layer. The optimized floating
pulsatile capsule provided the first pulse of the drug immediately after administration to
cover the first point of the symptoms. It provided the drug release from second pulse
after a lag time of 8 hr for covering up the second point of the symptoms in the early
morning. Conclusion: Thus, the dual-release floating pulsatile capsule designed may be
used for chronological treatment of hypertension.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-0099 |
Aim: Hypertension exhibits a circadian rhythm and drugs need to be released at the time
when the blood pressure is elevated most. This elevation is pronounced at 7 pm and at 4
am. Atenolol is an anti-hypertensive drug with an absorption window mainly in the upper
section of the gastrointestinal tract. The present investigation was aimed at designing
floating pulsatile capsules for dual release of atenolol in the stomach for effective
management of hypertension. Materials and Methods: The floating pulsatile capsules
designed had different components: a formaldehyde-treated capsule body; an untreated
cap; a polymer plug layer, containing a polymer; two atenolol-containing immediate-
release tablets and a swellable polymer layer. The polymer plug layer was made of
hydroxypropyl methylcellulose (K4M or E50) and xanthan gum alone or in combination.
The capsules were characterized for weight variation, percent drug content,
in-vitro
release behaviour and floating property. Results: The outcomes of the
in-vitro studies
showed that lag duration between the two pulses of drug release from the formulations
can be adjusted by manipulating the composition of the plug layer. The optimized floating
pulsatile capsule provided the first pulse of the drug immediately after administration to
cover the first point of the symptoms. It provided the drug release from second pulse
after a lag time of 8 hr for covering up the second point of the symptoms in the early
morning. Conclusion: Thus, the dual-release floating pulsatile capsule designed may be
used for chronological treatment of hypertension.
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