Formulation development and optimization of famotidine mucoadhesive tablets by central composite design
By: Chinthaginjala, Haranath
.
Contributor(s): Telkar, Mousami Bhavasar.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 1044-1051p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Objectives: The intention of present study is to formulate and optimize the famotidine
mucoadhesive tablets y using Central Composite Design. Materials and Methods: The
concentrations of
Cordia dichotoma fruit mucilage powder (X1) and Polyvinyl pyrrolidone
(X2) were demonstrated as independent variables. Whereas, the dependent variables
were selected such as an
in vitro Mucoadhesion Time and percentage Drug Release.
The model was considered to be nonlinear and the curvature effect was significant.
Hence, the study reported to Central Composite Design. By using wet granulation
method, the tablets were prepared and all the formulated tablets were evaluated for its
post compression parameters. Results: The drug and the excipients had no interaction,
according to FT-IR and DSC analyses. All formulations showed Mucoadhesion Time
ranging from 5 hr to 9 hr and % Drug Release in the range of 96.4% to 99.69%. The
association amongst the dependent variable and independent variables was judge by
using Contour plots. Conclusion: The outcomes indicated the efficacy of the proposed
design for famotidine Mucoadhesive tablets development.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-0101 |
Objectives: The intention of present study is to formulate and optimize the famotidine
mucoadhesive tablets y using Central Composite Design. Materials and Methods: The
concentrations of
Cordia dichotoma fruit mucilage powder (X1) and Polyvinyl pyrrolidone
(X2) were demonstrated as independent variables. Whereas, the dependent variables
were selected such as an
in vitro Mucoadhesion Time and percentage Drug Release.
The model was considered to be nonlinear and the curvature effect was significant.
Hence, the study reported to Central Composite Design. By using wet granulation
method, the tablets were prepared and all the formulated tablets were evaluated for its
post compression parameters. Results: The drug and the excipients had no interaction,
according to FT-IR and DSC analyses. All formulations showed Mucoadhesion Time
ranging from 5 hr to 9 hr and % Drug Release in the range of 96.4% to 99.69%. The
association amongst the dependent variable and independent variables was judge by
using Contour plots. Conclusion: The outcomes indicated the efficacy of the proposed
design for famotidine Mucoadhesive tablets development.
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