Enhanced solubility of meloxicam with sodium benzoate hydrotrope: ecofriendly approach for improved topical drug delivery
By: Tripathi, Devika
.
Contributor(s): Sharma, Dinesh Kumar.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 1052-1062p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: Hydrotropic solid dispersion has been reported as a potential process to
improve the poor solubility of drugs using conventional hydrotropes. The presented
investigation has described a water-soluble hydrotropic solid dispersion system for
Meloxicam (MX) using sodium benzoate hydrotrope to enhance the poor solubility
of Meloxicam and to improve topical delivery. Thus, solid dispersion was prepared,
characterized, and converted into HSD-Meloxicam gel. The prepared gel was further
characterized for
in vitro performance. Material and Methods: Solid dispersion was
prepared by a solvent evaporation method using sodium benzoate in 1:4 ratios. The
prepared systems were characterized for
in-vitro release and drug content. Accordingly,
rate-controlling polymer and drug penetration enhancers were selected and formulated
into hydrogel bases. The prepared gel was evaluated for performance parameters like drug
content, pH, viscosity, spreadability, drug release kinetics, diffusion study, accelerated
stability studies, and viscosity parameters. Results: HSD-Meloxicam gel containing
carbopol-934 (20%w/w) has appeared a 99% release of the drug over 60 min of time
duration. The prepared gel has clarity and is homogeneous in appearance. Similarly,
in-
vitro dissolution studies showed the prepared HSD Meloxicam gel’s better release and
rheological properties. The drug content of gel was found as 96% with improved topical
delivery.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-0102 |
Background: Hydrotropic solid dispersion has been reported as a potential process to
improve the poor solubility of drugs using conventional hydrotropes. The presented
investigation has described a water-soluble hydrotropic solid dispersion system for
Meloxicam (MX) using sodium benzoate hydrotrope to enhance the poor solubility
of Meloxicam and to improve topical delivery. Thus, solid dispersion was prepared,
characterized, and converted into HSD-Meloxicam gel. The prepared gel was further
characterized for
in vitro performance. Material and Methods: Solid dispersion was
prepared by a solvent evaporation method using sodium benzoate in 1:4 ratios. The
prepared systems were characterized for
in-vitro release and drug content. Accordingly,
rate-controlling polymer and drug penetration enhancers were selected and formulated
into hydrogel bases. The prepared gel was evaluated for performance parameters like drug
content, pH, viscosity, spreadability, drug release kinetics, diffusion study, accelerated
stability studies, and viscosity parameters. Results: HSD-Meloxicam gel containing
carbopol-934 (20%w/w) has appeared a 99% release of the drug over 60 min of time
duration. The prepared gel has clarity and is homogeneous in appearance. Similarly,
in-
vitro dissolution studies showed the prepared HSD Meloxicam gel’s better release and
rheological properties. The drug content of gel was found as 96% with improved topical
delivery.
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