Amelioration of hepato-renal impairment by natural chelators in lead-induced poisoning in rats
By: Quadri, Neha Nausheen
.
Contributor(s): Syed, Ayaz Ali.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 1123-1133p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: Hepato-Renal impairment refers to renal dysfunction in a liver compromised
state concerning lead metal exposure. Natural chelators (marine source) have potent
chelating properties claiming to ameliorate hepato-renal dysfunction in heavy metal
toxicity Material and Methods: A total of 42 male albino Wistar rats weighing between
200 to 250 g were categorised into seven groups (
n=6). Except for the first group
(control), which received sodium-acetate (1,000 mg/L in drinking water), all of the groups
received lead acetate 0.4 mg/kg body weight per oral (p.o). Second-group is the negative
control group (toxic), the third and fourth received Chitosan and Chitosamine 0.2 g/kg
(p.o) respectively. Ethylene diaminetetra acetic acid (EDTA) 495 mg/kg (p.o) was given to
the fifth, sixth, and seventh groups, whereas Chitosan and Chitosamine [0.2 g/kg (p.o)]
were given to the sixth and seventh groups, respectively. Results: There is statistical
significant increase in atherogenic indices, serum lipid profile, renal tissue oxidative-
stress, renal function biomarkers, kidney weights, and decrease in body weights of
experimental animals in the toxic as compared to control whereas these values ameliorated
in treatment groups as compared to toxic group. Histopathology of toxic group kidneys
revealed histologic and pathological changes in nephrons along with dyslipidemia which
healed to normal architecture and analytical values in treatment groups. Thus, the study
confirms the nephro protective effect and improvement of dyslipidemia as a consequence
of hepato-renal impairment by natural chelators. Conclusion: The natural chelators have
hepatic and nephro protective effect in lead metal induced poisoning.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-0110 |
Background: Hepato-Renal impairment refers to renal dysfunction in a liver compromised
state concerning lead metal exposure. Natural chelators (marine source) have potent
chelating properties claiming to ameliorate hepato-renal dysfunction in heavy metal
toxicity Material and Methods: A total of 42 male albino Wistar rats weighing between
200 to 250 g were categorised into seven groups (
n=6). Except for the first group
(control), which received sodium-acetate (1,000 mg/L in drinking water), all of the groups
received lead acetate 0.4 mg/kg body weight per oral (p.o). Second-group is the negative
control group (toxic), the third and fourth received Chitosan and Chitosamine 0.2 g/kg
(p.o) respectively. Ethylene diaminetetra acetic acid (EDTA) 495 mg/kg (p.o) was given to
the fifth, sixth, and seventh groups, whereas Chitosan and Chitosamine [0.2 g/kg (p.o)]
were given to the sixth and seventh groups, respectively. Results: There is statistical
significant increase in atherogenic indices, serum lipid profile, renal tissue oxidative-
stress, renal function biomarkers, kidney weights, and decrease in body weights of
experimental animals in the toxic as compared to control whereas these values ameliorated
in treatment groups as compared to toxic group. Histopathology of toxic group kidneys
revealed histologic and pathological changes in nephrons along with dyslipidemia which
healed to normal architecture and analytical values in treatment groups. Thus, the study
confirms the nephro protective effect and improvement of dyslipidemia as a consequence
of hepato-renal impairment by natural chelators. Conclusion: The natural chelators have
hepatic and nephro protective effect in lead metal induced poisoning.
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