Anti-diabetic effect of sprouted trigonella foenum- graecum l. seed solid dosage form in low-dose streptozotocin induced diabetic rats
By: Mishra, Ashwini Kumar
.
Contributor(s): Sahoo, Pravat Kumar.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 1156-1163p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background:
Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly
cultivated for its seed as well as for its sprouts. Pharmacological investigations reported
anti-bacterial, anti-diabetic, anti-cancer, anti-diarrheal, anti-hypercholesteremic, and anti-
inflammatory activities of
Trigonella foenum-graecum L. Aim: The purpose of this study
was to accentuate on formulation of granules and investigate the effect of germinated
Trigonella foenum-graecum L. (TFG) granules in Diabetes mellitus (DM) rats induced
by streptozotocin as fenugreek retains hypoglycemic property. Materials and Methods:
Granules of germinated TFG powder were arranged by means of several excipients
comprising diverse amounts of super disintegrants by (wet) granulation method and
proceed for the solid dosage form evaluation. Further,
in-vivo study was performed in
STZ induced DM Wister rats for four weeks. TFG granules 1600mg/kg and Glibenclamide
0.45 mg/kg (as a positive control for comparison) were orally administrated and evaluate
the diabetics in rats. Results: All evaluation parameter are correct: as in standard tablet.
The STZ (Streptozotocin) induced rats the treatment with the Drug (Glibenclamide) and
TFG granules significantly lowered the blood plasma glucose levels by 36% (mean ± SD
glucose 120 ± 0.6 mg/dL (
p < 0.001)) and 38% (mean ± SD glucose 114 ± 0.4 mg/dL;
p < 0.001) respectively after 4 weeks of treatment when compared to T2DM (Type
2 Diabetes mellitus) rats. Conclusion: Experimental studies had shown that bioactive
compounds found in
Trigonella Foenum graceum herb have potential to cure diabetes
especially due to the presence of unique chemical constituent including trigonelline,
galactomannan and amino acid 4-hydroxy isoleucine. These findings suggested that TFG
granules may be an alternative medicine for the management of DM.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-0117 |
Background:
Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly
cultivated for its seed as well as for its sprouts. Pharmacological investigations reported
anti-bacterial, anti-diabetic, anti-cancer, anti-diarrheal, anti-hypercholesteremic, and anti-
inflammatory activities of
Trigonella foenum-graecum L. Aim: The purpose of this study
was to accentuate on formulation of granules and investigate the effect of germinated
Trigonella foenum-graecum L. (TFG) granules in Diabetes mellitus (DM) rats induced
by streptozotocin as fenugreek retains hypoglycemic property. Materials and Methods:
Granules of germinated TFG powder were arranged by means of several excipients
comprising diverse amounts of super disintegrants by (wet) granulation method and
proceed for the solid dosage form evaluation. Further,
in-vivo study was performed in
STZ induced DM Wister rats for four weeks. TFG granules 1600mg/kg and Glibenclamide
0.45 mg/kg (as a positive control for comparison) were orally administrated and evaluate
the diabetics in rats. Results: All evaluation parameter are correct: as in standard tablet.
The STZ (Streptozotocin) induced rats the treatment with the Drug (Glibenclamide) and
TFG granules significantly lowered the blood plasma glucose levels by 36% (mean ± SD
glucose 120 ± 0.6 mg/dL (
p < 0.001)) and 38% (mean ± SD glucose 114 ± 0.4 mg/dL;
p < 0.001) respectively after 4 weeks of treatment when compared to T2DM (Type
2 Diabetes mellitus) rats. Conclusion: Experimental studies had shown that bioactive
compounds found in
Trigonella Foenum graceum herb have potential to cure diabetes
especially due to the presence of unique chemical constituent including trigonelline,
galactomannan and amino acid 4-hydroxy isoleucine. These findings suggested that TFG
granules may be an alternative medicine for the management of DM.
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