Evaluation of methanolic extract of polyherbal cream on DNCB-induced atopic dermatitis in wistar albino rats
By: Sivakumar, G
.
Contributor(s): Cerin, Mareena Philip.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 1164-1171p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background: Atopic dermatitis, is a multifactorial chronic inflammatory and immunological
disease affecting the skin, with the serious impact on psychological and life style of the
patients. Unique polyherbal combination of
Aloe vera, Erngium foetidum, Passiflora edulis,
Syzygium samarangense, based on established profile of relevant to anti-inflammatory,
immunomodulatory and anti-oxidant property and formulated as cream for effective
therapy. Materials and Methods: Wistar albino rats were induced AD by sensitisation of
DNCB-BSA on 1st day of 1st week followed by re-sensitisation of 1st day of each week
for additional 5 weeks to all group except control with intervention of Pimecrolimus and
low and high dose of MEPC for group-3, 4 and 5 respectively, however for group-1 and
2 no treatment was given. Parameters such as scratching behaviour, frequency and ear
thickness are recorded on a weekly basis, whereas the Serum total and IgE, ear weight
and histopathology were done at the end (42nd day) of experiment. Results: MPEC has
significant and dose dependent decrease in all parameters, the standard drug has highest
positive results with nearly equivalent result of high dose of MEPC in parameters such
as scratching behaviour, frequency, IgE and histopathology, however as in the case of
ear weight high dose of MEPC has more positive results than Pimecrolimus (standard
drug), reflecting MEPC has more immunomodulatory effect in long term use as compare
to Pimecrolimus. Conclusion: MEPC might provide good alternative therapy against the
treatment of AD to improve the life style of patient without ADR.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-0118 |
Background: Atopic dermatitis, is a multifactorial chronic inflammatory and immunological
disease affecting the skin, with the serious impact on psychological and life style of the
patients. Unique polyherbal combination of
Aloe vera, Erngium foetidum, Passiflora edulis,
Syzygium samarangense, based on established profile of relevant to anti-inflammatory,
immunomodulatory and anti-oxidant property and formulated as cream for effective
therapy. Materials and Methods: Wistar albino rats were induced AD by sensitisation of
DNCB-BSA on 1st day of 1st week followed by re-sensitisation of 1st day of each week
for additional 5 weeks to all group except control with intervention of Pimecrolimus and
low and high dose of MEPC for group-3, 4 and 5 respectively, however for group-1 and
2 no treatment was given. Parameters such as scratching behaviour, frequency and ear
thickness are recorded on a weekly basis, whereas the Serum total and IgE, ear weight
and histopathology were done at the end (42nd day) of experiment. Results: MPEC has
significant and dose dependent decrease in all parameters, the standard drug has highest
positive results with nearly equivalent result of high dose of MEPC in parameters such
as scratching behaviour, frequency, IgE and histopathology, however as in the case of
ear weight high dose of MEPC has more positive results than Pimecrolimus (standard
drug), reflecting MEPC has more immunomodulatory effect in long term use as compare
to Pimecrolimus. Conclusion: MEPC might provide good alternative therapy against the
treatment of AD to improve the life style of patient without ADR.
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