Adhatoda vasica possesses anti-microbial activity and effectively ameliorates ischemia reperfusion injury induced by doxorubicin through controlling oxidative stress
By: Almonther, Abdullah Hershan
.
Contributor(s): Abdulhaq, Ahmed A.
Publisher: Bangalore Association of Pharmaceutical Teachers of India (APTI) 2022Edition: Vol.56(4), Oct-Dec.Description: 1172-1180p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical education and researchSummary: Background and Objectives: Myocardial ischemia is one of the leading causes deaths
among cardiac pathological conditions. Doxorubicin belongs to anthracycline class of
drug which is effective against a wide variety of neoplasms. However, doxorubicin-
induced cardiotoxicity limits the clinical utility of the drug. One of the major causes of
myocardial ischemia is oxidative stress.
Adhatoda vasica have been shown to possess
strong anti-inflammatory during ischemia reperfusion injury induced by doxorubicin in
zebrafish model. Materials and Methods: Cardiac ischemia was induced in Zebrafish using
doxorubicin.
Adhatoda vasica was further supplemented and the antioxidants enzymes
were analysed. Zebrafish was also infected with MRSA and the anti-microbial activity
of
A. vasica was analysed. Results: Supplementation with
Adhatoda vasica extract to
doxorubicin reduces the oxidative stress induced by doxorubicin through improvement
of catalase, superoxide dismutase and GSH activities and subsequently reduces lipid
peroxidation. Doxorubicin mediated inflammatory response in cardiac tissue is neutralized
by supplementation with
Adhatoda vasica plant extract and improves the cardiac tissue
architecture.
A. vasica plant extract is effective against inhibiting the growth of MRSA
which has been shown to cause serious complications during cardiac surgery and cardiac
prosthetic implantation.
A. vasica plant extract causes a dose-dependent suppression of
virulence gens such as
spA and m
ecA. Conclusion: Therefore,
A. vasica extract may be
useful in controlling microbial infections during cardiac complications. In conclusion, the
present study indicates that
A. vasica can be useful during cardiac complications.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-0120 |
Background and Objectives: Myocardial ischemia is one of the leading causes deaths
among cardiac pathological conditions. Doxorubicin belongs to anthracycline class of
drug which is effective against a wide variety of neoplasms. However, doxorubicin-
induced cardiotoxicity limits the clinical utility of the drug. One of the major causes of
myocardial ischemia is oxidative stress.
Adhatoda vasica have been shown to possess
strong anti-inflammatory during ischemia reperfusion injury induced by doxorubicin in
zebrafish model. Materials and Methods: Cardiac ischemia was induced in Zebrafish using
doxorubicin.
Adhatoda vasica was further supplemented and the antioxidants enzymes
were analysed. Zebrafish was also infected with MRSA and the anti-microbial activity
of
A. vasica was analysed. Results: Supplementation with
Adhatoda vasica extract to
doxorubicin reduces the oxidative stress induced by doxorubicin through improvement
of catalase, superoxide dismutase and GSH activities and subsequently reduces lipid
peroxidation. Doxorubicin mediated inflammatory response in cardiac tissue is neutralized
by supplementation with
Adhatoda vasica plant extract and improves the cardiac tissue
architecture.
A. vasica plant extract is effective against inhibiting the growth of MRSA
which has been shown to cause serious complications during cardiac surgery and cardiac
prosthetic implantation.
A. vasica plant extract causes a dose-dependent suppression of
virulence gens such as
spA and m
ecA. Conclusion: Therefore,
A. vasica extract may be
useful in controlling microbial infections during cardiac complications. In conclusion, the
present study indicates that
A. vasica can be useful during cardiac complications.
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