Formulation and evaluation of yohimbine HCl proliposomal gels
By: Wajid Ahmad
.
Contributor(s): Rihan Jawed.
Publisher: Raipur Asian Pharma Press 2022Edition: Vol.12(4), Oct-Dec.Description: 302-306p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Asian journal of pharmaceutical researchSummary: The study was aimed to develop a proliposomal formulation for anti- inflammatory drug Yohimbine HCl. Proliposomes with various concentrations of mannitol, phospholipid and cholesterol were prepared using thin-film hydration technique (vacuum rotatory evaporator). The optimization of proliposomal formulation was achieved based on Average size, Entrapment efficiency and drug content. The proliposomal formulation was incorporated in the gel (carbopol) and characterized for their rheology and in vitro drug release studies. The results of formulations revealed that maximum entrapment efficiency was dependent on phospholipid and cholesterol concentration. Rheological studies revealed that the proliposome formulation containing 2% w/w carbopol is stable for topical drug delivery. The In-vitro studies revealed that proliposomal gel formulation exhibits increased skin permeation showing sustain release when compared to that of pure drug.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2023-0168 |
The study was aimed to develop a proliposomal formulation for anti- inflammatory drug Yohimbine HCl. Proliposomes with various concentrations of mannitol, phospholipid and cholesterol were prepared using thin-film hydration technique (vacuum rotatory evaporator). The optimization of proliposomal formulation was achieved based on Average size, Entrapment efficiency and drug content. The proliposomal formulation was incorporated in the gel (carbopol) and characterized for their rheology and in vitro drug release studies. The results of formulations revealed that maximum entrapment efficiency was dependent on phospholipid and cholesterol concentration. Rheological studies revealed that the proliposome formulation containing 2% w/w carbopol is stable for topical drug delivery. The In-vitro studies revealed that proliposomal gel formulation exhibits increased skin permeation showing sustain release when compared to that of pure drug.
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