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Synthesis of hybrid peptides from unnatural aminoacids

By: Srinivas, Avula.
Publisher: New Delhi CSIR 2022Edition: Vol.61, Nov.Description: 1199-1204p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here In: Indian journal of chemistry (Section B)Summary: Hexa peptide 10 has been prepared by the condensation of tetrapeptide acid and dipeptide amine by using standard coupling reagents EDCI, HOBT and DIPEA. In the same method, terta peptide 8 has also been prepared from the acid of dipeptide 6 and amine salt of dipeptide 7 in dichloromethane. Dipeptide 5 has been prepared from the unnatural amino acid which is prepared from D-Glucose and Xyloses. NMR spectral data of peptides indicates presence of secondary structure in peptides.
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Hexa peptide 10 has been prepared by the condensation of tetrapeptide acid and dipeptide amine by using standard coupling
reagents EDCI, HOBT and DIPEA. In the same method, terta peptide 8 has also been prepared from the acid of dipeptide 6 and
amine salt of dipeptide 7 in dichloromethane. Dipeptide 5 has been prepared from the unnatural amino acid which is prepared from
D-Glucose and Xyloses. NMR spectral data of peptides indicates presence of secondary structure in peptides.

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