New Ln(III) coordination polymer constructed from a hexadentate triazine ligand: Treatment activity and nursing value for ovarian cancer
By: Wang, Xiaoqin Wang
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Contributor(s): Zhang, Duoyi.
Publisher: New Delhi CSIR 2022Edition: Vol.61, Jan.Description: 31-36p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: In this current paper, a 3D lanthanide (Ln) coordination polymer (CP), compound 1 with a chemical formula of [(NH2(Me)2)]6·[Gd3(TATAT)2(μ2-O)1.5]·3EtOH·7.5H2O is synthesized with the reaction between GdCl3·6H2O and 5,5′,5′′-(1,3,5-triazine-2,4,6-triyltriimino)tris(azanediyl) triisophthalate (H6TATAT). Its treatment activity and nursing value against ovarian cancer is tested and the associated mechanism is analyzed simultaneously. At first, the CCK-8 detection is implemented to determine the suppression activity of compound 1 against the cell viability of ovarian cancer after treated via our compound. Furthermore, in order to detect the relative expression for the estrogen receptor on cells of ovarian cancer, real time RT-PCR is carried out.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2023-0672 |
In this current paper, a 3D lanthanide (Ln) coordination polymer (CP), compound 1 with a chemical formula of [(NH2(Me)2)]6·[Gd3(TATAT)2(μ2-O)1.5]·3EtOH·7.5H2O is synthesized with the reaction between GdCl3·6H2O and 5,5′,5′′-(1,3,5-triazine-2,4,6-triyltriimino)tris(azanediyl) triisophthalate (H6TATAT). Its treatment activity and nursing value against ovarian cancer is tested and the associated mechanism is analyzed simultaneously. At first, the CCK-8 detection is implemented to determine the suppression activity of compound 1 against the cell viability of ovarian cancer after treated via our compound. Furthermore, in order to detect the relative expression for the estrogen receptor on cells of ovarian cancer, real time RT-PCR is carried out.
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