Hepatoprotective potential of lycopene in a rat model of cisplatin-induced damage: involvement of oxidative cell damage and glutathione metabolism
By: Mladenovic, B
.
Contributor(s): Mihajlovic, I.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(4), Jul-Aug.Description: 988-998p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Application of cisplatin for the treatment of various solid tumors is known to cause liver damage, through an
increase in lipid peroxidation and reactive oxygen species production. Lycopene is a powerful antioxidant
agent capable of preventing the cells damage, the formation of stronger intercellular bonds and faster
cellular metabolism. This study aims to estimate the potential of lycopene in preventing cisplatin induced
liver tissue damage by studying the levels of several biochemical parameters (arginase, aminotransferases,
alkaline phosphatase, gamma-glutamyl transpeptidase activity, total protein and albumin concentration)
reflecting liver function and a panel of liver tissue biomarkers (xanthine oxidase, reduced glutathione,
malondialdehyde, protein carbonylated concentration and diamino oxidase activity). These parameters
would be studied in male Wistar rats treated with either cisplatin alone or with cisplatin and lycopene.
Additionally, microscopic analysis of liver tissue would be conducted as well. Application of the combination
of lycopene and cisplatin significantly prevented the disturbance in all here-studied biomarkers of liver
tissue damage. Morphological liver tissue alterations followed the changes in hepatic biochemical status.
Our results suggest that lycopene could act as a protective agent in cisplatin-induced liver damage in rats.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2023-0855 |
Application of cisplatin for the treatment of various solid tumors is known to cause liver damage, through an
increase in lipid peroxidation and reactive oxygen species production. Lycopene is a powerful antioxidant
agent capable of preventing the cells damage, the formation of stronger intercellular bonds and faster
cellular metabolism. This study aims to estimate the potential of lycopene in preventing cisplatin induced
liver tissue damage by studying the levels of several biochemical parameters (arginase, aminotransferases,
alkaline phosphatase, gamma-glutamyl transpeptidase activity, total protein and albumin concentration)
reflecting liver function and a panel of liver tissue biomarkers (xanthine oxidase, reduced glutathione,
malondialdehyde, protein carbonylated concentration and diamino oxidase activity). These parameters
would be studied in male Wistar rats treated with either cisplatin alone or with cisplatin and lycopene.
Additionally, microscopic analysis of liver tissue would be conducted as well. Application of the combination
of lycopene and cisplatin significantly prevented the disturbance in all here-studied biomarkers of liver
tissue damage. Morphological liver tissue alterations followed the changes in hepatic biochemical status.
Our results suggest that lycopene could act as a protective agent in cisplatin-induced liver damage in rats.
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