Recovery of diabetic ulcers facilitated by asiaticoside through activating the wnt/beta-catenin signalling cascade
By: Jun, Li
.
Contributor(s): Zhang, H.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(4), Jul-Aug.Description: 1006-1012p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Diabetic ulcers, a type of chronic and refractory wound, are the most common diabetic complication
and their incidence is increasing. However, the specific mechanisms underlying the formation of diabetic
ulcers have not been clarified and the current therapeutic methods are unsatisfactory. In this study,
we found that asiaticoside facilitated the recovery of skin wounds in diabetic rats. Intensive studies
demonstrated that asiaticoside promoted fibroblast proliferation and migration in a high-glycemic
environment. Mechanistically, asiaticoside upregulated Wnt1 at the protein and immunohistochemistry
levels and activated the Wnt/beta-catenin signaling cascade, thereby promoting fibroblast functions. Thus,
asiaticoside promotes skin cell activities relevant to diabetic ulcers healing and thus may have therapeutic
value.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2023-0857 |
Diabetic ulcers, a type of chronic and refractory wound, are the most common diabetic complication
and their incidence is increasing. However, the specific mechanisms underlying the formation of diabetic
ulcers have not been clarified and the current therapeutic methods are unsatisfactory. In this study,
we found that asiaticoside facilitated the recovery of skin wounds in diabetic rats. Intensive studies
demonstrated that asiaticoside promoted fibroblast proliferation and migration in a high-glycemic
environment. Mechanistically, asiaticoside upregulated Wnt1 at the protein and immunohistochemistry
levels and activated the Wnt/beta-catenin signaling cascade, thereby promoting fibroblast functions. Thus,
asiaticoside promotes skin cell activities relevant to diabetic ulcers healing and thus may have therapeutic
value.
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