Bone Tissue Regeneration: Rapid Prototyping Technology in Scaffold Design
By: Ansari, Ali Imran
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Contributor(s): Sheikh, Nazir Ahmad.
Publisher: Pune Springer 2022Edition: Vol,103(5), Oct.Description: 1303–1324p.Subject(s): Mechanical EngineeringOnline resources: Click here
In:
Journal of the institution of engineers (India): Series CSummary: systematic review refers to the advancement of Rapid Prototyped facilitated scaffolding for regeneration of tissue from the bone. Bone tissue is a mineralized tissue consisting of cortical bones and cancellous bones with two types of hard tissue structure. The bone's dense outer shell, often referred to as the compact bone, it makes up nearly 80% of the cortical bone's skeletal mass, While the cancellous part shares the remaining 20%. Many different forms of cells & substances are participating in the bone remodeling mechanism. Bone remodeling is a highly intricate mechanism in which osteocytes, osteoblasts, and osteoclasts work together to restore old bone with new bone. Osteoclasts are in charge of ageing bone resorption, while osteoblasts are in charge of new bone production. Osteocytes serve as mechanosensors and coordinators during bone remodeling. When used in combination with traditional methods, gas foaming, particulate leaching, fiber bonding, phase separation, lamination of membranes, melting, solvent casting, and freeze drying have been used to manufacture tissue-engineered structures. Although these scaffold manufacturing techniques do not help designers optimize internal architecture that could lead to the development of biological processes and tissues, they do have other benefits. In Rapid Prototyping (RP), complicated and convoluted structures can be successfully produced. Using “RP” in bone scaffold generation results in enhanced strength, in-vitro, and in-vivo cell culture, helps in increasing the capacity for patient-specific bone scaffolds design. This study evaluated the advantages of RP/imaging/CAD/CAM in making scaffolds for bone tissue reconstruction, and it is beneficial to those patients who were otherwise unable to be treated because of the conventional methods. The study explores the possible effects of RP on organ transplantation
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School of Engineering & Technology Archieval Section | Not for loan | 2023-0938 |
systematic review refers to the advancement of Rapid Prototyped facilitated scaffolding for regeneration of tissue from the bone. Bone tissue is a mineralized tissue consisting of cortical bones and cancellous bones with two types of hard tissue structure. The bone's dense outer shell, often referred to as the compact bone, it makes up nearly 80% of the cortical bone's skeletal mass, While the cancellous part shares the remaining 20%. Many different forms of cells & substances are participating in the bone remodeling mechanism. Bone remodeling is a highly intricate mechanism in which osteocytes, osteoblasts, and osteoclasts work together to restore old bone with new bone. Osteoclasts are in charge of ageing bone resorption, while osteoblasts are in charge of new bone production. Osteocytes serve as mechanosensors and coordinators during bone remodeling. When used in combination with traditional methods, gas foaming, particulate leaching, fiber bonding, phase separation, lamination of membranes, melting, solvent casting, and freeze drying have been used to manufacture tissue-engineered structures. Although these scaffold manufacturing techniques do not help designers optimize internal architecture that could lead to the development of biological processes and tissues, they do have other benefits. In Rapid Prototyping (RP), complicated and convoluted structures can be successfully produced. Using “RP” in bone scaffold generation results in enhanced strength, in-vitro, and in-vivo cell culture, helps in increasing the capacity for patient-specific bone scaffolds design. This study evaluated the advantages of RP/imaging/CAD/CAM in making scaffolds for bone tissue reconstruction, and it is beneficial to those patients who were otherwise unable to be treated because of the conventional methods. The study explores the possible effects of RP on organ transplantation
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