Screening of secondary metabolites and semi-synthetic analogues of ramalina leiodea (Nyl.) nyl. Against free radicals, inflammation and cancer cell lines
By: Killari, K. N
.
Contributor(s): Prasanth, D. S. N. B. K.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2023Edition: Vol.85(3), May-Jun.Description: 799-805p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The objective of the present study is to evaluate the pharmacological actions of earlier reported metabolites (1-5), and semi-synthetic analogs (4a-e) from acetone extract of Ramalina leiodea. The Acetone extract of Ramalina leiodea were screened for antioxidant, anti-inflammatory, anticancer, and acute toxicity studies. The antioxidant results exhibited that compound 4e showed effective inhibitory ability against ferric ions, 2,2-diphenyl-1-picrylhydrazyl and superoxide free radicals with 50 % inhibition value of 28.50, 27.0, and 25.0 μg/ml, respectively. Also, among all the samples, 4e revealed good inhibition of albumin denaturation of 105 μg/ml (IC50 value). Additionally, the median lethal dosage of acetone extract of Ramalina leiodea was observed to be above 2000 mg/Kg body weight. Also, the in vivo antiinflammatory studies of acetone extract of Ramalina leiodea exhibited a noticeable reduction of edema in rat paw at both low and high dosage when compared to indomethacin. From the sulforhodamine B assay, it is concluded that 2 and 4b displayed a noteworthy degree of specificity against tested series of cell lines. On the other hand, all tested samples displayed a low degree of specificity against normal cells. To conclude, Ramalina leiodea could be the best source for bioactive agents for the management of oxidative stress, inflammation, and cancer.
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2024-0215 |
The objective of the present study is to evaluate the pharmacological actions of earlier reported metabolites (1-5), and semi-synthetic analogs (4a-e) from acetone extract of Ramalina leiodea. The Acetone extract of Ramalina leiodea were screened for antioxidant, anti-inflammatory, anticancer, and acute toxicity studies. The antioxidant results exhibited that compound 4e showed effective inhibitory ability against ferric ions, 2,2-diphenyl-1-picrylhydrazyl and superoxide free radicals with 50 % inhibition value of 28.50, 27.0, and 25.0 μg/ml, respectively. Also, among all the samples, 4e revealed good inhibition of albumin denaturation of 105 μg/ml (IC50 value). Additionally, the median lethal dosage of acetone extract of Ramalina leiodea was observed to be above 2000 mg/Kg body weight. Also, the in vivo antiinflammatory studies of acetone extract of Ramalina leiodea exhibited a noticeable reduction of edema in rat paw at both low and high dosage when compared to indomethacin. From the sulforhodamine B assay, it is concluded that 2 and 4b displayed a noteworthy degree of specificity against tested series of cell lines. On the other hand, all tested samples displayed a low degree of specificity against normal cells. To conclude, Ramalina leiodea could be the best source for bioactive agents for the management of oxidative stress, inflammation, and cancer.
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