Phellinus igniarius represses oral squamous cell carcinoma cell development via up-regulating microRNA-655-3p
By: Deying, Li
.
Contributor(s): Tingting, Xu.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2023Edition: Vol.85(4), Jul-Aug.Description: 1144-1149p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: To explore the influence and possible mechanism of extracts from Phellinus igniarius (expanded
program on immunization) on oral squamous cell carcinoma cell proliferation, migration and invasion.
CAL27 cells were treated with expanded program on immunization or transfected with microRNA-
655-3p. Furthermore, transfected CAL27 cells were exposed to 600 μg/ml expanded program on
immunization. Proliferation, migration and invasion were assessed using 3-(4,5-dimethylthiazole-2-yl)-
2,5-diphenyltetrazolium bromide and Transwell. Matrix metallopeptidase 2, matrix metallopeptidase 9
and proliferating cell nuclear antigen protein levels were monitored using Western blot. After various
doses of expanded program on immunization, cell viability, migration, invasion, proliferating cell nuclear
antigen, matrix metallopeptidase 2 and matrix metallopeptidase 9 protein levels were reduced, but
microRNA-655-3p content was enhanced in a dose-dependent way. Meanwhile, increased microRNA-655-
3p might diminish cell proliferation, migration and invasion. Beyond that, microRNA-655-3p knockdown
overturned high-dose expanded program on immunization-mediated tumor development repression.
Expanded program on immunization could hinder oral squamous cell carcinoma cell development via
modulating microRNA-655-3p.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2024-0425 |
To explore the influence and possible mechanism of extracts from Phellinus igniarius (expanded
program on immunization) on oral squamous cell carcinoma cell proliferation, migration and invasion.
CAL27 cells were treated with expanded program on immunization or transfected with microRNA-
655-3p. Furthermore, transfected CAL27 cells were exposed to 600 μg/ml expanded program on
immunization. Proliferation, migration and invasion were assessed using 3-(4,5-dimethylthiazole-2-yl)-
2,5-diphenyltetrazolium bromide and Transwell. Matrix metallopeptidase 2, matrix metallopeptidase 9
and proliferating cell nuclear antigen protein levels were monitored using Western blot. After various
doses of expanded program on immunization, cell viability, migration, invasion, proliferating cell nuclear
antigen, matrix metallopeptidase 2 and matrix metallopeptidase 9 protein levels were reduced, but
microRNA-655-3p content was enhanced in a dose-dependent way. Meanwhile, increased microRNA-655-
3p might diminish cell proliferation, migration and invasion. Beyond that, microRNA-655-3p knockdown
overturned high-dose expanded program on immunization-mediated tumor development repression.
Expanded program on immunization could hinder oral squamous cell carcinoma cell development via
modulating microRNA-655-3p.
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