Antimicrobial profiles, antidiarrheal and antipyretic capacities of phenol, acid rich-fractions from ximenia america I.., (olacaceae) in wistar albino rats
By: Kiessoun, Konate
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Contributor(s): Roland, Meda Nag Tiero | Mamounata, Diao.
Publisher: M. P. Innovare Academic Sciences Pvt Ltd 2018Edition: Vol. 10(10), July-August.Description: 62-68.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective: The present study aim to evaluate antimicrobial and antidiarrheal activities of phenol acid-rich fractions of roots from Ximeniaamericana L. , in animal models in order to confirm the ethnomedicinal use of Ximenia Americana L., roots. Methods: In vitro antibacterial (Minimum inhibitory concentration (MIC), Minimum bactericidal concentration (MBC) and time-kill studies) of phenol-rich fractions of roots fromXimenia americana L., was assessed using eight bacteria strains (Gram-negative). The anti-diarrheal activity was evaluated using castor using castor oil induced diarrhea whereas Anti-secretory activity was investigated using castor oil-induced enteropoolingassay examined in animal models respectively. Results: All test bacteria were susceptible to the phenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viablemicroorganism in the initial inoculum. Moreover, phenol acid-rich fractions of roots (100-200 and 300 mg/kg, p. o.) produced dose-dependent and significant (p<0.05-0.001) protection of rats against castor oil-induced diarrhea, and delayed gastric emptying. Phenol acid-rich fractions of roots, dose-dependently and significantly (p<0.05-0.001) delayed the onset of castor oil induced diarrhea, decreased the frequency of defecation, and reduced the severity of diarrhea in the rats. Phenol acid-rich fractions caused dose-related inhibition of castor-oil-induced enteropooling in rats. Conclusion: The data analysis indicates that the tested of phenol-rich fractions has significant effects when compared with the standard antibiotic. These results, therefore, justify the traditional use of Ximenia americanaL. About antidiarrheal activity, the findings of this study indicate that phenol acid-rich fraction possesses antidiarrheal property in rats. These findings ....
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School of Pharmacy Archieval Section | Not for loan | 2018418 |
Objective: The present study aim to evaluate antimicrobial and antidiarrheal activities of phenol acid-rich fractions of roots from Ximeniaamericana L. , in animal models in order to confirm the ethnomedicinal use of Ximenia Americana L., roots. Methods: In vitro antibacterial (Minimum inhibitory concentration (MIC), Minimum bactericidal concentration (MBC) and time-kill studies) of phenol-rich fractions of roots fromXimenia americana L., was assessed using eight bacteria strains (Gram-negative). The anti-diarrheal activity was evaluated using castor using castor oil induced diarrhea whereas Anti-secretory activity was investigated using castor oil-induced enteropoolingassay examined in animal models respectively. Results: All test bacteria were susceptible to the phenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viablemicroorganism in the initial inoculum. Moreover, phenol acid-rich fractions of roots (100-200 and 300 mg/kg, p. o.) produced dose-dependent and significant (p<0.05-0.001) protection of rats against castor oil-induced diarrhea, and delayed gastric emptying. Phenol acid-rich fractions of roots, dose-dependently and significantly (p<0.05-0.001) delayed the onset of castor oil induced diarrhea, decreased the frequency of defecation, and reduced the severity of diarrhea in the rats. Phenol acid-rich fractions caused dose-related inhibition of castor-oil-induced enteropooling in rats. Conclusion: The data analysis indicates that the tested of phenol-rich fractions has significant effects when compared with the standard antibiotic. These results, therefore, justify the traditional use of Ximenia americanaL. About antidiarrheal activity, the findings of this study indicate that phenol acid-rich fraction possesses antidiarrheal property in rats. These findings ....
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