Food-drug interaction and their clinical implications :Selected investigations
By: Elgadir, M. Abd
.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol. 2(3).Description: 1-5p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Food
-
drug interactions occur as a result of pharmacokinetic
or
pharmacodynamics
mechanisms
. Pharmacokinetic
mechanisms include what the
body does to a drug while
Pharmacodynamics
mechanisms involve what
drugs do
to the body.
Many types of food have been shown to influence
metabolism
and the absorption of drugs.
Large numbers of drugs are produced and introduced yearly. The interaction between Food and drug may
cause
negative
effects in the nutritional status of the patient as well as saf
ety and efficacy of drug therapy. Due to the possibility of unexpected or
poor outcomes, generally, food
-drug interactions
, in this case,
should be avoided. As
the
good
clinical practice
, drugs taken by mouth must be
absorbed
either
through
the lining
of
the
stomach or the small intestine.
Reduction
in the
absorbance of a drug might be influenced by t
he presence
of food in the digestive tract.
The avoidance of such interactions could be possible if the drug is taken 1 hour before or 2 h
after eating
the fo
od
. The
effects of s
everal
types of food such as milk or milk products, grapefruit and grapefruit juice, bananas, oranges, legumes
, fermented
meats and
pickled fish and some nutrient elements such as calcium, potassium, magnesium, iron, zinc
, and
vitamin K
are highlighted in this paper
including
their
clinical implications
.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2018551 |
Food
-
drug interactions occur as a result of pharmacokinetic
or
pharmacodynamics
mechanisms
. Pharmacokinetic
mechanisms include what the
body does to a drug while
Pharmacodynamics
mechanisms involve what
drugs do
to the body.
Many types of food have been shown to influence
metabolism
and the absorption of drugs.
Large numbers of drugs are produced and introduced yearly. The interaction between Food and drug may
cause
negative
effects in the nutritional status of the patient as well as saf
ety and efficacy of drug therapy. Due to the possibility of unexpected or
poor outcomes, generally, food
-drug interactions
, in this case,
should be avoided. As
the
good
clinical practice
, drugs taken by mouth must be
absorbed
either
through
the lining
of
the
stomach or the small intestine.
Reduction
in the
absorbance of a drug might be influenced by t
he presence
of food in the digestive tract.
The avoidance of such interactions could be possible if the drug is taken 1 hour before or 2 h
after eating
the fo
od
. The
effects of s
everal
types of food such as milk or milk products, grapefruit and grapefruit juice, bananas, oranges, legumes
, fermented
meats and
pickled fish and some nutrient elements such as calcium, potassium, magnesium, iron, zinc
, and
vitamin K
are highlighted in this paper
including
their
clinical implications
.
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