http://www.ijpsonline.com/articles/fabrication-and-characterization-of-selfmicroemulsifying-mouth-dissolving-film-for-effective-delivery-of-piroxicam.pdf
By: Pattewar, Seema
.
Contributor(s): Pande, V.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2019Edition: Vol. 81(3), May-June.Description: 503-513p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Self-microemulsifying drug delivery systems are widely used to address water-solubility issues of drug candidates, but with these systems, there is a chance of drug precipitation due to migration of the surfactant in the shell of capsule. Piroxicam is a class II drug that exhibits poor solubility and high permeability. Efforts were made to develop piroxicam self-microemusifying mouth dissolving fi lm using a polymer such as hydroxylpropyl methylcellulose as a fi lm-forming polymer and optimized using response surface methodology of Design-Expert® software version 10. A sublingual self-microemusifying mouth dissolving fi lm was prepared that disintegrated in 26 seconds. The in vitro drug release of self-microemusifying mouth dissolving fi lm was 98.04±0.016% in 5 min. The newly developed sublingual self-microemusifying mouth dissolving fi lm provided rapid absorption of piroxicam (tmax ~2 h) and suitable for providing a rapid onset of analgesic action.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2019665 |
Self-microemulsifying drug delivery systems are widely used to address water-solubility issues of drug candidates, but with these systems, there is a chance of drug precipitation due to migration of the surfactant in the shell of capsule. Piroxicam is a class II drug that exhibits poor solubility and high permeability. Efforts were made to develop piroxicam self-microemusifying mouth dissolving fi lm using a polymer such as hydroxylpropyl methylcellulose as a fi lm-forming polymer and optimized using response surface methodology of Design-Expert® software version 10. A sublingual self-microemusifying mouth dissolving fi lm was prepared that disintegrated in 26 seconds. The in vitro drug release of self-microemusifying mouth dissolving fi lm was 98.04±0.016% in 5 min. The newly developed sublingual self-microemusifying mouth dissolving fi lm provided rapid absorption of piroxicam (tmax ~2 h) and suitable for providing a rapid onset of analgesic action.
Click on an image to view it in the image viewer
There are no comments for this item.