Electrospinning of Hydroxypropyl-beta-cyclodextrin/Polyvinylpyrrolidone Resveratrol-loaded Nanofibers: Preparation and Characterization
- Vol. 81 (04)
- Mumbai Indian Journal of Pharmaceutical Science 2019
- 618-625p.
In the present study, hydroxypropyl-β-cyclodextrin-polyvinylpyrrolidone-loaded resveratrol nanofibers were prepared via electrospinning to achieve higher water solubility of resveratrol. The hydroxypropyl-β-cyclodextrin-polyvinylpyrrolidone-loaded resveratrol electrospinning nanofibers were characterized with scanning electron microscopy, Fourier-transform infrared spectroscopy, Raman spectroscopy, differential scanning calorimetry, and ultraviolet irradiation test. Results obtained indicated successful encapsulation of resveratrol in hydroxypropyl-β-cyclodextrin- polyvinylpyrrolidone nanofibers, the diameter of the fiber could reach nanoscale and resveratrol existed in an amorphous state. The ultraviolet irradiation test demonstrated that the resveratrol electrospinning nanofibers were more stable than pure resveratrol when exposed to ultraviolet light. The solubility test indicated that the resveratrol electrospinning nanofibers had better water-solubility than pure resveratrol. Furthermore, the in vitro release study indicated that resveratrol electrospinning nanofibers achieved slow and sustained resveratrol release.