FORMULATION DEVELOPMENT AND EVALUATION OF ORALLY DI SINTEGRATING TABLET OF CHLORPHENERAMINE MALEATE BY SUBLIMATION TECHNIQUE
- Vol.11(9)
- M P Innovare Academic Sciences Pvt Ltd 2019
- 28-36p.
Objective: Chlorpheneramine maleate is a first-generation anti histamine drug used in the treatment of allergic co nditions like rhinitis, urticaria, and cough cold, etc. In present work, the challenge has been made to develop an orally disintegrating tablet of chlorpheneramine maleate with an increase in bioavailability and patient compliance. Methods: The sublimation technique was used to prepare orall y disintegrating tablets. Porous tablet prepared af ter sublimation of camphor at 60 °C in a hot air oven for 60 min. In the research wo rk, 3 2 full factorial design used to find out the effect o f two variables like the amount of Crospovidone and Croscarmellose sodium. Results: All prepared formulations were analyzed for various parameters. DSC of pure drug and optimized formula tion A (9) showed purity of sample and compatibility of all ingredients with each other. I n FTIR study of pure drug and optimized formulation A (9) no major shifts were seen. An optimized formulation (A9) was found to have good hardness (3 .2 kg/cm2), friability (<1 %), disintegration time (26 s), % drug release (99.77 %) within 6 min. Conclusion: The result obtained showed that orally disintegrati ng tablet of chlorpheneramine maleate enhances diss olution rate, improves bioavailability which will improve patient complian ce.