SYNTHESIS AND UTILITY OF NEW POLYCYCLIC COMPOUNDS A S POTENTIAL ANTIMICROBIALS BASED ON CHROMENE MOIETY
- Vol.11(9)
- M P Innovare Academic Sciences Pvt Ltd 2019
- 49-56p.
Objective: The present research aims to synthesize some new po lycyclic compounds including chromene moiety and st udy their antimicrobial activity. Methods: Several new polycyclic systems including chromene s caffold incorporated with pyridine, pyrimidine, imi dazopyrimidine, and imidazodiazocine were achieved via condensation reaction of chromene derivative under the proper condition with various reagents namely; cyanothioacetamide, phenyl isothiocyanate, malononi trile, carbon disulfide, benzaldehyde, triethylorth oformate, and 1,4-dichlorobutane. Moreover, a chlorodiazenyl chromene derivative was reacted wi th some substances possessing active–CH 2 -bridge such as ethyl cyanoacetate and malononitrile to end up with hydrazono compounds. S uch compounds were eventually cyclized with hydrazi ne hydrate to form pyrazole and oxopyrazole derivatives. Moreover, compound 1 was treated with benzoyl acetone, and then followed by cyclization with malononitrile to provide the corresponding 2-amino14-(4-methoxyphenyl)-4-met hy-5-phenyl-14H-benzo[5,6] chromeno [2,3H][1,6]napht hyridine-3-carbonitrile (20). Results: The results of the antimicrobial screening in vitro revealed that the inhibition zone (mm) of the synt hesized compounds 1-3, 5 and 8 implied their optimum antibacterial activity, while the compounds 4, 6 and 9-13, 15 showed a moderate to weak antibacterial activity against multiple species of B. subtilis, S. aureus, E. coli and P. aeruginosa . In contrast, the compounds 1, 6, 11, 15 showed hi gh antifungal activities against different species of A. flavinand C. albicans , while the other compounds exhibit a moderate to p oor antifungal activity. Conclusion: It is remarkable that a series of chromene derivati ves synthesized by a simple and available method le ads to a molecule of promising antimicrobial activity. Further research is recomme nded to approve the importance of polycyclic system s for various applications.