IN VITRO ANTI -INFLAMMATORY ACTIVITY OF SYRINGIC ACID
- Vol.11(2)
- M P Innovare Academic Sciences Pvt Ltd 2019
- 71-73p.
Objective: The present study was carried out to investigate the in vitro anti -inflammatory activity of syringic acid (SA). Method s: SA was tested for it's in vitro anti -inflammatory activity at different concentrations in protein denaturation, proteinase inhibition and human red blood cell (HRBC) membrane stabilization assay. The reference drugs used were aspirin and diclofenac sodium. Result s: SA showed concentration -dependent inhibition of protein denaturation and proteinase activity with a half -maximal inhibitory concentration ( IC 50 ) value of 49.38 ±0.56 μg /ml and 53.73 ±0.27 μg /ml respectively. Heat- induced haemolysis was inhibited by SA with an IC 50 value of 57.13 ±0. 24 μg /ml . SA also inhibit ed the hypotonicity -induced haemolysis (IC 50 Conclusio n: From the present study, we can conclude that SA possesses appreciable anti -inflammatory effect against denaturation of proteins, proteinase activity , and human red blood membrane stabilization assays. Further studies are required for determining the possible mechanisms behind its anti -inflammatory action.