SYNTHESIS AND ANTICANCER SCREENING OF TRIAZINE ANAL OGUES
- Vol.11(4)
- M P Innovare Academic Sciences Pvt Ltd 2019
- 114-121p.
Objective: The study was aimed to investigate the cytotoxic ef fect of S-5H -[1,2,4]-triazino (5,6- b ) indol-3-yl-3,4-phenylethane-thioate derivatives a s epidermal growth factor Receptor (EGFR) inhibitors. Methods: In the present study 14 novel triazine analogues we re synthesized and characterized using different sp ectroscopic techniques such as FT- IR, NMR and Mass Spectroscopy. The anticancer activ ity was performed using MCF-7 (breast cancer) and K -562 (leukaemia) cell lines. Further, molecular docking was carried out using Vlife Molec ular Docking Software (MDS) on crystal structure of epidermal growth factor receptor (EGFR) to identify the binding mode of interaction with an active site. Results: Compounds MA-7, MA-8, MA-12, MA-13 and MA-14 show p otent activity against cancer cell lines in the ran ge of<10 to 84.4 μg/ml. Further molecular docking on EGFR also supports that there is a strong correlation between in silico and in vitro biological activity. The results of this study may be further useful for lead optimization process .