Saravanan, S. <br/><br/>
LC -MS/MS STUDY OF THE TRACE LEVEL IMPURITIES OF IRBESARTAN AN ANGIOTENSIN II  RECEPTOR ANTAGONIST MOLECULE TO ITS ORIGIN THROUGH n MS 

 - Vol.11(1) 
 - M P  Innovare Academic Sciences Pvt Ltd  2019 
 - 38-43p. 
<br/><br/> Objective: <br/>The<br/>  mass  characteriz<br/>ation<br/>  of    five <br/>trace  level  related  impurities  of  Irbesartan  was  performed  through  the  “nMS2”  technique  of  triple  <br/>quadrupole mass spectrometer and also to <br/>Correlated<br/> to the impurity origin.<br/>Method<br/>s: <br/>A  simple <br/>&  effective<br/>  patented  process  was  applied  to  get  the  impurity  profile,<br/>  and<br/>  mass <br/>characteri<br/>zation<br/>  was  performed  through  the  <br/>“nMS2” technique of triple quadrupole <br/>mass <br/>spectrometer<br/> analyser.<br/>Result<br/>s: <br/>The  simple  production  scan  in  differential  collision  energies  is  coined  as  “nMS2”  technique  of  the  triple  quadrupole  analyzer. <br/>The <br/>molecular  ion  fragmentation  occurs  with  multiple  collision  energies  <br/>and<br/>  provides  meaningful  MSMS  fragments  for  characterizing<br/>  five  trace  l<br/>evel <br/>impurities  less  than  0.5%  <br/>of  angiotensin  II  receptor  antagonist<br/>-Irbesartan<br/>.  Th<br/>e  origin  of  the  impurity  formation  in  the  synthetic  process  was<br/>successfully <br/>related to the<br/> Spiro ketones.<br/>Conclusio<br/>n: <br/>The  results  obtained  in  this  research  clearly  indicates  the  approach  of  “nM 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS