Anitha, K. <br/><br/>
ANTIHYPERLIPIDEMIC EFFECT OF ETHANOLIC SEED EXTRACT OF  CANAVALIA ENSIFORMIS ( L)  IN HIGH FAT DIET -STREPTOZOTOCIN INDUCED RATS 

 - Vol.11(1) 
 - M P  Innovare Academic Sciences Pvt Ltd  2019 
 - 99-102p. 
<br/><br/> Objective: <br/>It was investigated to enlighten the phytochemical screening and<br/> antihyperlipidemic <br/>activity <br/>of seeds of <br/>Canavalia ensiformis (L.)<br/> in High <br/>fat diet Streptozotocin<br/>-induced<br/> diabetic rats.<br/>Method<br/>s: <br/>The <br/>e<br/>thanolic  seed  extract  of  <br/>Canavalia  ensiformis  <br/>(EECE)  at  a  dose  of  40<br/>0  mg<br/>/kg  and  200  mg/kg  was  administered  to  diabetic  r<br/>ats. <br/>Simvastatin (<br/>4 mg/kg) is used as <br/>a standard<br/> drug. <br/>Result<br/>s: <br/>The  statistics  <br/>were<br/>  assessed  by  using  one  way  ANOVA  followed  by  Dunnet’s  multiple  comparison  tests.  To  unfold  the  mechanism  we  <br/>studied <br/>all  the  biochemical  parameters  like <br/>Total  cholesterol  (T<br/>C),  Triglycerides<br/>  (TG), <br/>high<br/>-density<br/>  lipoproteins<br/>  (HDL<br/>), <br/>low<br/>-density<br/>  lipoproteins <br/>(LDL<br/>) and histopathological examination of Liver tissue section. The ethanolic extracts of seeds of <br/>Canavalia ensiformis<br/> showed significant reduce<br/> of <br/>the <br/>level<br/> of cholesterol<br/>, triglycerides, LDL, VLDL and <br/>a   significant<br/> increase in the serum level of HDL at 40<br/>0 mg<br/>/kg rather than 200 mg/kg.<br/>Conclusio<br/>n: <br/>Further the characterization and isolation of the constituents could be done to know the exact mechanism of hyperlipidemic ac<br/>tiv<br/>ity. <br/>Statistical  analysis  of  this  screening  method  conforms<br/>  that  the  proposed  method  is  <br/>appropriate<br/>  and  it  can  be  useful,  gives  the  basic  idea  to  the  <br/>researcher who is working in <br/>an <br/>area<br/> like Antihyperlipidemic activity.  
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS