DESIGN AND DEVELOPMENT OF NANOSTRUCTURED LIPID CARRIER CONTAINING TRIAMCINOLONE ACETONIDE
- Vol.11(12)
- M P Innovare Academic Sciences Pvt Ltd 2019
- 26-35p.
Objective: The aim of present study was to prepare nano structured lipid carriers (NLCs ) based Triamcinolone acetonide (TA) . Method s: Nanostructured lipid carriers (NLC s) consisted of solid lipid and liquid lipid are a new type of lipid nanoparticles, prepared by using solvent diffusion and high pressure homogenization methods , which offer the advantage of improved drug loading capacity and release properties. Glyceryl monostearate selected as the solid lipid, c apmul MCM C8 as the liquid lipid, p olyvinyl Alcohol (PVA) as the surfactant. NLCs dispersion was characterized by particle size analysis, zeta potential, scanning electron microscopy (SEM) , differential scanning calorimetry, and an in vitro release study. Result s: Optimized NLCs loaded with TA were exhibited spherical shape with particle size 286. 1 nm , polydispersity index 0.317 , zeta potential -21.9 mV and entrapment efficiency 86.19 % respectively . The result of differential scanning c alorimetry (DSC ) showed that drug was dispersed in NLC s in a crystalline state. In vitro release studies revealed that drug release of optimized batch was 8.34 % and 88.84 % at 1h and 8h respectively. The release kinetics of the optimized NLC s best fitted the p eppas -korsmeyer model. Furthermore, morphological investigations by SEM showed that optimized batch exhibit a spherical shape and a smooth surface. Conclusio n: Thus, the results indicated that successfully prepared TA- loaded NLC s and could potentially be exploited as a carrier with improved drug loading capacity and sustained drug release. The p resent results demonstrated that these systems could be a promising platform for inflammatory diseases, in particular for psoriasis topical th erapy.