Design, in silico analysis, synthesis, and evaluation of novel benzofused nitrogen-containing heterocyclic N-substituted mercaptobenzimidazole derivatives as potential antimicrobial agent
- Vol.15 (3), Jul-Sept
- Mandsaur B.R. Nahata Smriti Sansthan 2021
- 226-237p.
Background: There is an urgent need for buy soma online overnight delivery the development of novel antimicrobial drugs due to the rapid development of antimicrobial drug resistance. Benzimidazole containing mercapto group at 2-position is attractive nucleus for modification with wider pharmacological activities. Objective: The aim of this study is to design benzofused nitrogen-containing heterocyclic derivatives of mercaptobenzimidazole using molecular docking, synthesis of active derivative and evaluation as potential antimicrobial agent. Materials and Methods: Using an effective procedure, N-substituted mercaptobenzimidazole derivatives were synthesized based on the literature review. The antimicrobial activity of all synthesized compounds was tested against four different organisms: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. Molecular docking of mercaptobenzimidazole derivatives against DNA gyrase subunit B Protein Data Bank (PDB): 5l3j and S. aureus tyrosyl-tRNA synthetase PDB: 1jij was performed using docking protocol. The compound binds to buy soma online usa the active site of DNA gyrase subunit B (1KZN) in a docking study, indicating that it may have antimicrobial activity. Conclusion: The compounds MB3 and MB5 have antimicrobial capacity, according to the findings of this report. MB4 has the high activity against C. albicans.